دورية أكاديمية
Association Analyses Identify Three Susceptibility Loci for Vitiligo in the Chinese Han Population
| العنوان: | Association Analyses Identify Three Susceptibility Loci for Vitiligo in the Chinese Han Population |
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| المؤلفون: | Tang, Xian-Fa, Zhang, Zheng, Hu, Da-Yan, Xu, Ai-E, Zhou, Hai-Sheng, Sun, Liang-Dan, Gao, Min, Gao, Tian-Wen, Gao, Xing-Hua, Chen, Hong-Duo, Xie, Hong-Fu, Tu, Cai-Xia, Hao, Fei, Wu, Ri-Na, Zhang, Fu-Ren, Liang, Ling, Pu, Xiong-Ming, Zhang, Jian-Zhong, Han, Jian-Wen, Pan, Gong-Pu, Wu, Jia-Qiang, Li, Kai, Su, Ming-Wan, Du, Wei-Dong, Zhang, Wei-Jia, Liu, Jian-Jun, Xiang, Lei-Hong, Yang, Sen, Zhou, You-Wen, Zhang, Xue-Jun |
| المساهمون: | Xiang, LH (reprint author), Fudan Univ, Huashan Hosp, Dept Dermatol, 12 Urumqizhong Rd, Shanghai 200433, Peoples R China., Anhui Med Univ, Dept Dermatol & Venereol, Hefei 230032, Anhui, Peoples R China., Anhui Med Univ, Hosp 1, Inst Dermatol, Hefei 230032, Anhui, Peoples R China., Anhui Med Univ, Hosp 1, Dept Dermatol, Hefei 230032, Anhui, Peoples R China., Third Peoples Hosp Hangzhou, Dept Dermatol, Hangzhou, Zhejiang, Peoples R China., Fourth Mil Med Univ, Xijing Hosp, Dept Dermatol, Xian 710032, Peoples R China., China Med Univ, Hosp 1, Dept Dermatol, Shenyang, Peoples R China., Cent S Univ, Xiangya Hosp, Dept Dermatol, Changsha, Hunan, Peoples R China., Dalian Med Univ, Affiliated Hosp 2, Dept Dermatol, Dalian, Peoples R China., Third Mil Med Univ, Southwest Hosp, Dept Dermatol, Chongqing, Peoples R China., Inner Mongolia Med Coll, Affiliated Hosp, Dept Dermatol, Hohhot, Peoples R China., Shandong Prov Inst Dermatol & Venereol, Dept Dermatol, Jinan, Peoples R China., Guangxi Med Univ, Affiliated Hosp 1, Dept Dermatol, Nanning, Peoples R China., Peoples Hosp Xinjiang Uygur Autonomous Reg, Dept Dermatol, Urumqi, Peoples R China., Peking Univ, Peoples Hosp, Dept Dermatol, Beijing 100871, Peoples R China., Fudan Univ, Huashan Hosp, Dept Dermatol, Shanghai 200433, Peoples R China., Univ British Columbia, Dept Dermatol & Skin Sci, Vancouver, BC V5Z 4E8, Canada., Mt Sinai Sch Med, Dept Med, New York, NY USA., Fudan Univ, Huashan Hosp, Dept Dermatol, 12 Urumqizhong Rd, Shanghai 200433, Peoples R China. |
| المصدر: | SCI |
| بيانات النشر: | journal of investigative dermatology |
| سنة النشر: | 2013 |
| المجموعة: | Peking University Institutional Repository (PKU IR) / 北京大学机构知识库 |
| مصطلحات موضوعية: | GENOME-WIDE ASSOCIATION, GENERALIZED VITILIGO, AUTOIMMUNE-DISEASES, COMMON VARIANTS, T-CELLS, LINKAGE, EPIDEMIOLOGY, FAMILIES, GENETICS, GENES |
| الوصف: | To identify susceptibility loci for vitiligo, we extended our previous vitiligo genome-wide association study with a two-staged replication study that included 6,857 cases and 12,025 controls from the Chinese Han population. We identified three susceptibility loci, 12q13.2 (rs10876864, P-combined = 8.07 X 10(-12), odds ratio (OR) = 1.18), 11q23.3 (rs638893, P-combined = 2.47 x 10(-9), OR = 1.22), and 10q22.1 (rs1417210, P-combined = 1.83 x 10(-8), OR = 0.88), and confirmed three previously reported loci for vitiligo, 3q28 (rs9851967, P-combined = 8.57 x 10(-8), OR = 0.88), 10p15.1 (rs3134883, P-combined = 1.01 x 10(-5), OR = 1.11), and 22q12.3 (rs2051582, P-combined = 2.12 x 10(-5), OR = 1.14), in the Chinese Han population. The most significant single-nucleotide polymorphism in the 12q13.2 locus is located immediately upstream of the promoter region of PMEL, which encodes a major melanocyte antigen and has expression loss in the vitiligo lesional skin. In addition, both 12q13.2 and 11q23.3 loci identified in this study are also associated with other autoimmune diseases such as type 1 diabetes and systemic lupus erythematosus. These findings provide indirect support that vitiligo pathogenesis involves a complex interplay between immune regulatory factors and melanocyte-specific factors. They also highlight similarities and differences in the genetic basis of vitiligo in Chinese and Caucasian populations. Journal of Investigative Dermatology (2013) 133, 403-410; doi:10.1038/jid.2012.320; published online 6 September 2012 ; Dermatology ; SCI(E) ; 0 ; ARTICLE ; 2 ; 403-410 ; 133 |
| نوع الوثيقة: | journal/newspaper |
| اللغة: | English |
| تدمد: | 0022-202X 1523-1747 |
| العلاقة: | JOURNAL OF INVESTIGATIVE DERMATOLOGY.2013,133,(2),403-410.; 906905; http://hdl.handle.net/20.500.11897/394819Test; WOS:000313668000019 |
| DOI: | 10.1038/jid.2012.320 |
| الإتاحة: | https://doi.org/20.500.11897/394819Test https://doi.org/10.1038/jid.2012.320Test https://hdl.handle.net/20.500.11897/394819Test |
| رقم الانضمام: | edsbas.1DD25D28 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 0022202X 15231747 |
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| DOI: | 10.1038/jid.2012.320 |