دورية أكاديمية
Genetic Etiology and Dental Pulp Cell Deficiency of Hypophosphatasia
| العنوان: | Genetic Etiology and Dental Pulp Cell Deficiency of Hypophosphatasia |
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| المؤلفون: | Liu, H., Li, J., Lei, H., Zhu, T., Gan, Y., Ge, L. |
| المساهمون: | Ge, L (reprint author), Zhongguancun S Ave 22, Beijing 100081, Peoples R China., Peking Univ, Dept Pediat Dent, Sch Stomatol, Beijing 100871, Peoples R China., Peking Univ, Dept Pediat Dent, Hosp Stomatol, Beijing 100871, Peoples R China., Peking Univ, Cent Lab, Hosp Stomatol, Beijing 100871, Peoples R China., Peking Univ, Cent Lab, Sch Stomatol, Beijing 100871, Peoples R China., Zhongguancun S Ave 22, Beijing 100081, Peoples R China. |
| المصدر: | PubMed ; SCI |
| بيانات النشر: | journal of dental research |
| سنة النشر: | 2010 |
| المجموعة: | Peking University Institutional Repository (PKU IR) / 北京大学机构知识库 |
| مصطلحات موضوعية: | hypophosphatasia, tissue-non-specific alkaline phosphatase, gene mutation, dental pulp cells, NONSPECIFIC ALKALINE-PHOSPHATASE, STRUCTURAL EVIDENCE, MINERALIZATION, MUTATIONS, CULTURES, TEETH |
| الوصف: | Hypophosphatasia is caused by mutations of the tissue-non-specific alkaline phosphatase (TNSALP) gene with deficiency of dentin structure. The aim of this study was to examine whether TNSALP mutation in dental pulp cells contributes to dentin dysplasia in hypophosphatasia. Mutation analysis showed that compound heterozygous mutations of TNSALP were identified in three hypophosphatasia patients, including 3 novel mutation sites. Exfoliated teeth from the patients showed abnormal dentin mineralization and loss of cementum, as assessed by ground sections and scanning electron microscope analysis. Dental pulp cells isolated from one of the patients showed a significantly reduced TNSALP activity and mineralization capacity when compared with those in dental pulp cells from the unaffected individuals. Our results suggested that dentin dysplasia in hypophosphatasia may be associated with the decreased mineralization ability of dental pulp cells. ; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000284531100006&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701Test ; Dentistry, Oral Surgery & Medicine ; SCI(E) ; PubMed ; 7 ; ARTICLE ; 12 ; 1373-1377 ; 89 |
| نوع الوثيقة: | journal/newspaper |
| اللغة: | English |
| تدمد: | 0022-0345 |
| العلاقة: | JOURNAL OF DENTAL RESEARCH.2010,89,(12),1373-1377.; 668493; http://hdl.handle.net/20.500.11897/344685Test; WOS:000284531100006 |
| DOI: | 10.1177/0022034510379017 |
| الإتاحة: | https://doi.org/20.500.11897/344685Test https://doi.org/10.1177/0022034510379017Test https://hdl.handle.net/20.500.11897/344685Test |
| رقم الانضمام: | edsbas.37A843F1 |
| قاعدة البيانات: | BASE |
| تدمد: | 00220345 |
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| DOI: | 10.1177/0022034510379017 |