دورية أكاديمية
Cyclodextrins as buffer additives for the enantiomeric separation of pinacidil in capillary zone electrophoresis
| العنوان: | Cyclodextrins as buffer additives for the enantiomeric separation of pinacidil in capillary zone electrophoresis |
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| المؤلفون: | Wang, Z, Huang, AJ, Sun, YL, Sun, ZP |
| المساهمون: | BEIJING UNIV,DEPT CHEM,BEIJING 100817,PEOPLES R CHINA., NATL INST CONTROL PHARMACEUT & BIOL PROD,BEIJING 100050,PEOPLES R CHINA. |
| المصدر: | SCI |
| بيانات النشر: | journal of chromatography a |
| سنة النشر: | 1996 |
| المجموعة: | Peking University Institutional Repository (PKU IR) / 北京大学机构知识库 |
| مصطلحات موضوعية: | buffer composition, enantiomer separation, pinacidil, CHIRAL SEPARATION, THEORETICAL ASPECTS |
| الوصف: | The enantiomeric separation of pinacidil was studied using alpha-cyclodextrin (alpha-CD), beta-CD, heptakis (2,6-di-O-methyl)-beta-CD (DM-beta-CD), hydroxypropyl-beta-CD (HP-beta-CD) and gamma-CD as buffer additives at acidic pH in capillary zone electrophoresis. beta-CD, HP-beta-CD and gamma-CD all showed chiral recognition on the compound, with HP-beta-CD giving the highest chiral selectivity. Buffer concentration and HP-beta-CD concentration were optimized for the separation. The separation was improved by the addition of hydroxypropyl cellulose (HPC) to the buffer. A complete separation of pinacidil enantiomers was achieved by using 100 mM Tris-H3PO4 buffer (pH 2.3) containing 9 mM HP-beta-CD and 0.05% HPC. ; Biochemical Research Methods ; Chemistry, Analytical ; SCI(E) ; 0 ; ARTICLE ; 1-2 ; 300-303 ; 749 |
| نوع الوثيقة: | journal/newspaper |
| اللغة: | English |
| تدمد: | 0021-9673 |
| العلاقة: | JOURNAL OF CHROMATOGRAPHY A.1996,749,(1-2),300-303.; 1023991; http://hdl.handle.net/20.500.11897/258239Test; WOS:A1996VR64700038 |
| DOI: | 10.1016/0021-9673(96)00431-1 |
| الإتاحة: | https://doi.org/20.500.11897/258239Test https://doi.org/10.1016/0021-9673Test(96)00431-1 https://hdl.handle.net/20.500.11897/258239Test |
| رقم الانضمام: | edsbas.66093B60 |
| قاعدة البيانات: | BASE |
| تدمد: | 00219673 |
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| DOI: | 10.1016/0021-9673(96)00431-1 |