رسالة جامعية

Fiber Tracking and Fiber Tract Segmentation Using Diffusion Tensor Imaging

التفاصيل البيبلوغرافية
العنوان: Fiber Tracking and Fiber Tract Segmentation Using Diffusion Tensor Imaging
المؤلفون: Ye, Chuyang
المساهمون: Prince, Jerry L., Tran, Trac Duy, Goutsias, John I.
بيانات النشر: Johns Hopkins University
USA
سنة النشر: 2015
المجموعة: Johns Hopkins University, Baltimore: JScholarship
مصطلحات موضوعية: diffusion tensor imaging, fiber tract
الوصف: Diffusion tensor imaging (DTI) has become a popular tool for noninvasively investigating fiber tract structures. Fiber tracking and tract segmentation are two major tasks in DTI studies. However, fiber crossing is a well known issue in DTI because DTI cannot model crossing fiber orientations (FOs). Therefore, fiber tracking and tract segmentation methods that are able to address crossing fibers are needed. In this thesis, three contributions are made to the development of such fiber tracking and tract segmentation algorithms. First, a fiber tracking method guided by volumetric tract segmentation is presented. Tract segmentation contains anatomical information which can reduce the errors caused by crossing fibers and noise. The FO estimation problem is formulated in a Bayesian framework and the resulting objective function is solved with calculus of variations. The proposed method is able to reduce false positive fibers and generate fibers that correspond to known anatomy. It is also applied to a brain connectome study to show its potential scientific application. Second, we present an algorithm for resolving crossing fibers in situations where limited diffusion gradient directions are achievable. In particular, the algorithm is focused on interdigitated tongue muscles. It incorporates prior knowledge on likely FOs to account for the insufficient information due to limited diffusion gradient directions. Using maximum a posteriori estimation, FOs can be estimated by solving a weighted $\ell_{1}$-norm regularized least squares minimization. The method is shown to reduce the effect of noise and resolve crossing fibers with limited DTI. The distributions of the computed FOs in both the controls and the patients were also compared, suggesting a potential clinical use for this methodology. Third, a white matter tract segmentation method is proposed. The method focuses on the cerebellar peduncles, which are major white matter tracts in the cerebellum. The method uses volumetric segmentation concepts based on extracted ...
نوع الوثيقة: thesis
وصف الملف: application/pdf
اللغة: English
العلاقة: http://jhir.library.jhu.edu/handle/1774.2/40665Test
الإتاحة: http://jhir.library.jhu.edu/handle/1774.2/40665Test
رقم الانضمام: edsbas.680E0C8
قاعدة البيانات: BASE