IFITM proteins drive type 2 T helper cell differentiation and exacerbate allergic airway inflammation
| العنوان: | IFITM proteins drive type 2 T helper cell differentiation and exacerbate allergic airway inflammation |
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| المؤلفون: | Yánez, Diana C., Sahni, Hemant, Ross, Susan, Solanki, Anisha, Lau, Ching‐In, Papaioannou, Eleftheria, Barbarulo, Alessandro, Powell, Rebecca, Lange, Ulrike C., Adams, David J., Barenco, Martino, Ono, Masahiro, D'Acquisto, Fulvio, Furmanski, Anna L., Crompton, Tessa |
| المصدر: | European Journal of Immunology |
| بيانات النشر: | John Wiley and Sons Inc., 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, Interleukin-27, Interferon‐inducible transmembrane (IFITM) protein, T helper 1 (Th1), Cellular differentiation, Allergic airway disease, Immunology, Adaptive immunity, Respiratory System, Biology, Lymphocyte Activation, 03 medical and health sciences, Interferon-gamma, Mice, 0302 clinical medicine, Th2 Cells, Downregulation and upregulation, Immunopathology, Hypersensitivity, Immunology and Allergy, Animals, Secretion, T helper 2 (Th2), Basic, IFN‐γ, Gene, Th1-Th2 Balance, Interleukin 4, Research Articles, Cells, Cultured, Inflammation, Mice, Knockout, Membrane Proteins, Cell Differentiation, Th1 Cells, Acquired immune system, Transmembrane protein, Cell biology, Mice, Inbred C57BL, 030104 developmental biology, 030220 oncology & carcinogenesis, Research Article|Basic, Interleukin-4 |
| الوصف: | The interferon‐inducible transmembrane (Ifitm/Fragilis) genes encode homologous proteins that are induced by IFNs. Here, we show that IFITM proteins regulate murine CD4+ Th cell differentiation. Ifitm2 and Ifitm3 are expressed in wild‐type (WT) CD4+ T cells. On activation, Ifitm3 was downregulated and Ifitm2 was upregulated. Resting Ifitm‐family‐deficient CD4+ T cells had higher expression of Th1‐associated genes than WT and purified naive Ifitm‐family‐deficient CD4+ T cells differentiated more efficiently to Th1, whereas Th2 differentiation was inhibited. Ifitm‐family‐deficient mice, but not Ifitm3‐deficient mice, were less susceptible than WT to induction of allergic airways disease, with a weaker Th2 response and less severe disease and lower Il4 but higher Ifng expression and IL‐27 secretion. Thus, the Ifitm family is important in adaptive immunity, influencing Th1/Th2 polarization, and Th2 immunopathology. |
| اللغة: | English |
| تدمد: | 1521-4141 0014-2980 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d0f50e5477fe1b28059e8398f2b3396Test http://europepmc.org/articles/PMC6396086Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....4d0f50e5477fe1b28059e8398f2b3396 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15214141 00142980 |
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