Drugs used for the treatment of cerebral and disseminated infections caused by free‐living amoebae
| العنوان: | Drugs used for the treatment of cerebral and disseminated infections caused by free‐living amoebae |
|---|---|
| المؤلفون: | Philippe M. Loiseau, Zineb Fechtali-Moute, Alexandre Taravaud, Sébastien Pomel |
| المصدر: | Clinical and Translational Science Clinical and Translational Science, Vol 14, Iss 3, Pp 791-805 (2021) |
| بيانات النشر: | John Wiley and Sons Inc., 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Drug, 030213 general clinical medicine, media_common.quotation_subject, Reviews, Central Nervous System Protozoal Infections, RM1-950, Balamuthia, Review, 030226 pharmacology & pharmacy, General Biochemistry, Genetics and Molecular Biology, Balamuthia mandrillaris, 03 medical and health sciences, 0302 clinical medicine, parasitic diseases, Medicine, Humans, Amebicides, General Pharmacology, Toxicology and Pharmaceutics, Granulomatous amoebic encephalitis, Amoeba, media_common, Naegleria fowleri, biology, business.industry, General Neuroscience, Meningoencephalitis, Acanthamoeba infection, General Medicine, Amebiasis, biology.organism_classification, medicine.disease, Acanthamoeba, Survival Rate, Treatment Outcome, Immunology, Drug Therapy, Combination, Therapeutics. Pharmacology, Public aspects of medicine, RA1-1270, business |
| الوصف: | Free‐living amoebae (FLAs) are protozoa developing autonomously in diverse natural or artificial environments. The FLAs Acanthamoeba spp., Balamuthia mandrillaris, and Naegleria fowleri represent a risk for human health as they can become pathogenic and cause severe cerebral infections, named granulomatous amoebic encephalitis (GAE), Balamuthia amoebic encephalitis (BAE), and primary amoebic meningoencephalitis (PAM), respectively. Additionally, Acanthamoeba sp. can also rarely disseminate to diverse organs, such as the skin, sinuses, or bones, and cause extracerebral disseminated acanthamebiasis (EDA). No consensus treatment has been established for cerebral FLA infections or EDA. The therapy of cerebral and disseminated FLA infections often empirically associates a large diversity of drugs, all exhibiting a high toxicity. Nevertheless, these pathologies lead to a high mortality, above 90% of the cases, even in the presence of a treatment. In the present work, a total of 474 clinical cases of FLA infections gathered from the literature allowed to determine the frequency of usage, as well as the efficacy of the main drugs and drug combinations used in the treatment of these pathologies. The efficacy of drug usage was determined based on the survival rate after drug administration. The most efficient drugs, drug combinations, and their mechanism of action were discussed in regard to the present recommendations for the treatment of GAE, EDA, BAE, and PAM. At the end, this review aims to provide a useful tool for physicians in their choice to optimize the treatment of FLA infections. |
| اللغة: | English |
| تدمد: | 1752-8062 1752-8054 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b761a3f8f4e4ddb2a752733eeabd7a7Test http://europepmc.org/articles/PMC8212752Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....3b761a3f8f4e4ddb2a752733eeabd7a7 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17528062 17528054 |
|---|