دورية أكاديمية
Down-regulated miRs specifically correlate with non-cardial gastric cancers and Lauren's classification system
| العنوان: | Down-regulated miRs specifically correlate with non-cardial gastric cancers and Lauren's classification system |
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| المؤلفون: | LORENZON, LAURA, Cippitelli, Claudia, Avantifiori, Riccardo, UCCINI, Stefania, FRENCH, Deborah, TORRISI, Maria Rosaria, RANIERI, DANILO, MERCANTINI, Paolo, Canu, Valeria, Blandino, Giovanni, CAVALLINI, Marco |
| المساهمون: | Lorenzon, Laura, Cippitelli, Claudia, Avantifiori, Riccardo, Uccini, Stefania, French, Deborah, Torrisi, Maria Rosaria, Ranieri, Danilo, Mercantini, Paolo, Canu, Valeria, Blandino, Giovanni, Cavallini, Marco |
| بيانات النشر: | John Wiley and Sons Inc. P.O.Box 18667 |
| سنة النشر: | 2017 |
| المجموعة: | Sapienza Università di Roma: CINECA IRIS |
| مصطلحات موضوعية: | gastric cancer, lauren classification, mir148a, mir204, mir31, mir375, non-cardial gastric cancer, adenocarcinoma, adult, age factor, aged, 80 and over, cell line, tumor, down-regulation, female, gene expression regulation, neoplastic, human, janus kinase 2, male, microrna, middle aged, prognosi, protein-serine-threonine kinase, proto-oncogene proteins c-bcl-2, pyruvate dehydrogenase (acetyl-transferring) kinase, roc curve, repressor protein, retrospective studie |
| الوصف: | Background and Objectives: Gastric cancers are usually characterized using Lauren's classification into intestinal and diffuse types. We previously documented the down-modulation of miR31, miR148a, miR204, and miR375 in gastric cancers. We aimed this manuscript to investigate these miRs with the end-points of diagnosis, Lauren's classification and prognosis. Methods: A total of 117 resected non-cardial adenocarcinomas were evaluated for miRs' expressions. The performance of miRs’ expressions for cancer diagnosis was tested using ROC curves. Logistic regression was conducted with the end-point of Lauren's classification. Kaplan-Meier and Cox analyses were performed for OS, DFS, and DSS. miRs’ targets were reviewed using PRISMA method and BCL-2 was further investigated in cell lines. Results: ROC curves documented that miRs’ down-modulation was significant in differentiating cancer versus normal tissues. Diffuse type cancers were associated with female sex, young age, and miR375 higher expression. We confirmed BCL-2 as a miR204 target. However, survival analyses confirmed the pathologic criteria (advanced stages, LNR, and low LNH) as the significant variables correlated to worse prognosis. Conclusions: The down-modulation of miR31, miR148a, miR204, and miR375 is significantly associated with non-cardial gastric cancers and miR375 is specifically linked to Lauren's classification. Nevertheless, standard pathological features display as the independent variables associated with worse prognosis. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | ELETTRONICO |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/28475823; info:eu-repo/semantics/altIdentifier/wos/WOS:000406075500009; volume:116; issue:2; firstpage:184; lastpage:194; numberofpages:11; journal:JOURNAL OF SURGICAL ONCOLOGY; http://hdl.handle.net/11573/1434758Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85018410715 |
| DOI: | 10.1002/jso.24648 |
| الإتاحة: | https://doi.org/10.1002/jso.24648Test http://hdl.handle.net/11573/1434758Test |
| حقوق: | info:eu-repo/semantics/closedAccess |
| رقم الانضمام: | edsbas.E73C0643 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/jso.24648 |
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