Building clinically relevant outcomes across the Alzheimer's disease spectrum
| العنوان: | Building clinically relevant outcomes across the Alzheimer's disease spectrum |
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| المؤلفون: | Anna-Karin Berger, David Miller, Chris J. Edgar, Christopher Randolph, Ananth Annapragada, Michael Gold, Lisa J. Bain, Christopher J. Weber, Dominic Trépel, David S. Knopman, Glen Wunderlich, J. Michael Ryan, Alette M. Wessels, Dorene M. Rentz, Maria C. Carrillo, Megan Canniere Zoschg, Adam M. Staffaroni |
| المصدر: | Alzheimer's & Dementia : Translational Research & Clinical Interventions Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 7, Iss 1, Pp n/a-n/a (2021) |
| بيانات النشر: | John Wiley and Sons Inc., 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, medicine.medical_specialty, Disease, 03 medical and health sciences, 0302 clinical medicine, Research Roundtable, Disease severity, Medicine, Dementia, Treatment effect, Cognitive decline, RC346-429, treatment, business.industry, Disease spectrum, RC952-954.6, Alzheimer's disease, medicine.disease, cognitive decline, Psychiatry and Mental health, 030104 developmental biology, Geriatrics, Family medicine, Perspective, clinical meaningfulness, Neurology (clinical), Neurology. Diseases of the nervous system, business, 030217 neurology & neurosurgery, dementia |
| الوصف: | Demonstrating that treatments are clinically meaningful across the Alzheimer's disease (AD) continuum is critical for meeting our goals of accelerating a cure by 2025. While this topic has been a focus of several Alzheimer's Association Research Roundtable (AARR) meetings, there remains no consensus as to what constitutes a “clinically meaningful outcome” in the eyes of patients, clinicians, care partners, policymakers, payers, and regulatory bodies. Furthermore, the field has not come to agreement as to what constitutes a clinically meaningful treatment effect at each stage of disease severity. The AARR meeting on November 19–20, 2019, reviewed current approaches to defining clinical meaningfulness from various perspectives including those of patients and care partners, clinicians, regulators, health economists, and public policymakers. Participants discussed approaches that may confer clinical relevance at each stage of the disease continuum and fostered discussion about what should guide us in the future. |
| اللغة: | English |
| تدمد: | 2352-8737 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a85e7355fdc2ba7584fc00bdfc484edTest http://europepmc.org/articles/PMC8234696Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....7a85e7355fdc2ba7584fc00bdfc484ed |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 23528737 |
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