دورية أكاديمية
Exploring the emotional and behavioural profile in paediatric narcolepsy type 1: A case–control study
| العنوان: | Exploring the emotional and behavioural profile in paediatric narcolepsy type 1: A case–control study |
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| المؤلفون: | Simoncini Malucelli G., Mercante A., Pizza F., Brunetti V., Biscarini F., Vandi S., Mazzoni A., Franceschini C., Della Marca G., Vollono C., Chieffo D. P. R., Plazzi G. |
| المساهمون: | Simoncini Malucelli, G., Mercante, A., Pizza, F., Brunetti, V., Biscarini, F., Vandi, S., Mazzoni, A., Franceschini, C., Della Marca, G., Vollono, C., Chieffo, D. P. R., Plazzi, G. |
| بيانات النشر: | John Wiley and Sons Inc |
| سنة النشر: | 2023 |
| المجموعة: | Università di Parma: CINECA IRIS |
| مصطلحات موضوعية: | emotional and behavioural functioning, narcolepsy type 1, paediatric, psychological profile, psychometrics |
| الوصف: | Narcolepsy type 1 (NT1) is a central disorder of hypersomnolence often arising in childhood and adolescence. NT1 has a significant, but poorly defined, psychological impact. We aimed to investigate the psycho-social functioning of children and adolescents with NT1. We performed a cross-sectional, child and parent-reported questionnaire survey in 37 children and adolescents (6–17 years) with NT1, compared with age- and sex-matched controls. Questionnaires (SSHS, ESS-CHAD, CDI, MASC, CBCL, CRS-R, and SNAP-IV) evaluated various aspects of behavioural and emotional profiles, sleep habits, and daytime sleepiness. Subsequently, NT1 intra-group analysis was performed to investigate the effect of sex (males vs females) and pharmacological treatment (treated vs non-treated) on psychological features. The NT1 questionnaires total scores were then correlated with the clinical characteristics (age, body mass index [BMI], ESS-CHAD score, cerebrospinal hypocretin-1 [Hcrt-1] levels, and diagnostic delay). Patients with NT1 showed a higher tendency to depressive symptoms, anxiety, somatisation, inattention, hyperactivity, oppositional/defiant problems, and other maladaptive behaviours compared with controls. Among NT1 patients, females showed a higher propensity to anxiety, and non-treated patients displayed higher depressive symptoms. Psychological symptoms increased with age, BMI, and daytime sleepiness in patients with NT1, while a younger age was associated with more frequent somatisation symptoms. Lower cerebrospinal Hcrt-1 levels correlated with poorer social competencies, daily activities, and inattention. Diagnostic delay was associated with a higher impact of depressive symptoms and behavioural problems. NT1 in children and adolescents is associated with poorer functioning in multiple psychological domains calling for a multidisciplinary approach and monitoring to reduce disease burden and to prevent psychiatric consequences. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/wos/WOS:001088022800001; firstpage:1; lastpage:13; numberofpages:13; journal:JOURNAL OF SLEEP RESEARCH; https://hdl.handle.net/11381/2965997Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85174610284 |
| DOI: | 10.1111/jsr.14064 |
| الإتاحة: | https://doi.org/10.1111/jsr.14064Test https://hdl.handle.net/11381/2965997Test |
| رقم الانضمام: | edsbas.4689046F |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/jsr.14064 |
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