دورية أكاديمية
Breaking and Making of Rings: A Method for the Preparation of 4-Quinolone-3-carboxylic Acid Amides and the Expensive Drug Ivacaftor
| العنوان: | Breaking and Making of Rings: A Method for the Preparation of 4-Quinolone-3-carboxylic Acid Amides and the Expensive Drug Ivacaftor |
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| المؤلفون: | Vasudevan, N., Jachak, Gorakhnath R., Reddy, D. Srinivasa |
| بيانات النشر: | John Wiley and Sons |
| سنة النشر: | 2015 |
| المجموعة: | Indian Academy of Sciences: Publication of Fellows |
| مصطلحات موضوعية: | QD Chemistry |
| الوصف: | A simple and convenient method to access 4-quinolone-3-carboxylic acid amides from indole-3-acetic acid amides through one-pot oxidative cleavage of the indole ring followed by condensation (Witkop–Winterfeldt type oxidation) was explored. The scope of the method was confirmed with more than 20 examples and was successfully applied to the synthesis of the drug Ivacaftor, the most expensive drug on the market |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| العلاقة: | Vasudevan, N.; Jachak, Gorakhnath R.; Reddy, D. Srinivasa (2015) Breaking and Making of Rings: A Method for the Preparation of 4-Quinolone-3-carboxylic Acid Amides and the Expensive Drug Ivacaftor European Journal of Organic Chemistry, 2015 (34). pp. 7433-7437. ISSN 1434-193X |
| DOI: | 10.1002/ejoc.201501048 |
| الإتاحة: | https://doi.org/10.1002/ejoc.201501048Test http://repository.ias.ac.in/121942Test/ |
| رقم الانضمام: | edsbas.33AEEDAF |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/ejoc.201501048 |
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