دورية أكاديمية
Protein target highlights in CASP15 : analysis of models by structure providers
| العنوان: | Protein target highlights in CASP15 : analysis of models by structure providers |
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| المؤلفون: | Alexander, Leila T., Durairaj, Janani, Kryshtafovych, Andriy, Abriata, Luciano A., Bayo, Yusupha, Bhabha, Gira, Breyton, Cécile, Caulton, Simon G., Chen, James, Degroux, Séraphine, Ekiert, Damian C., Erlandsen, Benedikte S., Freddolino, Peter L., Gilzer, Dominic, Greening, Chris, Grimes, Jonathan M., Grinter, Rhys, Gurusaran, Manickam, Hartmann, Marcus D., Hitchman, Charlie J., Keown, Jeremy R., Kropp, Ashleigh, Kursula, Petri, Lovering, Andrew L., Lemaitre, Bruno, Lia, Andrea, Liu, Shiheng, Logotheti, Maria, Lu, Shuze, Markússon, Sigurbjörn, Miller, Mitchell D., Minasov, George, Niemann, Hartmut H., Opazo, Felipe, Phillips, George N., Davies, Owen R., Rommelaere, Samuel, Rosas‐Lemus, Monica, Roversi, Pietro, Satchell, Karla, Smith, Nathan, Wilson, Mark A., Wu, Kuan‐Lin, Xia, Xian, Xiao, Han, Zhang, Wenhua, Zhou, Z. Hong, Fidelis, Krzysztof, Topf, Maya, Moult, John, Schwede, Torsten |
| بيانات النشر: | John Wiley & Sons Ltd. |
| سنة النشر: | 2023 |
| المجموعة: | The University of Warwick: WRAP - Warwick Research Archive Portal |
| الوصف: | We present an in-depth analysis of selected CASP15 targets, focusing on their biological and functional significance. The authors of the structures identify and discuss key protein features and evaluate how effectively these aspects were captured in the submitted predictions. While the overall ability to predict three-dimensional protein structures continues to impress, reproducing uncommon features not previously observed in experimental structures is still a challenge. Furthermore, instances with conformational flexibility and large multimeric complexes highlight the need for novel scoring strategies to better emphasize biologically relevant structural regions. Looking ahead, closer integration of computational and experimental techniques will play a key role in determining the next challenges to be unraveled in the field of structural molecular biology. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | unknown |
| العلاقة: | https://wrap.warwick.ac.uk/179886/7/WRAP-protein-target-highlights-CASP15-analysis-models-structure-providers-2024.pdfTest; Alexander, Leila T., Durairaj, Janani, Kryshtafovych, Andriy, Abriata, Luciano A., Bayo, Yusupha, Bhabha, Gira, Breyton, Cécile, Caulton, Simon G., Chen, James, Degroux, Séraphine et al. (2023) Protein target highlights in CASP15 : analysis of models by structure providers. Proteins: Structure, Function, and Bioinformatics, 91 (12). pp. 1571-1599. doi:10.1002/prot.26545 ISSN 0887-3585. |
| DOI: | 10.1002/prot.26545 |
| الإتاحة: | https://doi.org/10.1002/prot.26545Test https://wrap.warwick.ac.uk/179886Test/ https://wrap.warwick.ac.uk/179886/7/WRAP-protein-target-highlights-CASP15-analysis-models-structure-providers-2024.pdfTest |
| رقم الانضمام: | edsbas.1C75A43B |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/prot.26545 |
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