Presence of diabetes mellitus and steatosis is associated with liver stiffness in a general population: The Rotterdam study
| العنوان: | Presence of diabetes mellitus and steatosis is associated with liver stiffness in a general population: The Rotterdam study |
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| المؤلفون: | Laurent Castera, Bruno H. Stricker, Bettina E. Hansen, Sarwa Darwish Murad, Elisabeth P.C. Plompen, Albert Hofman, Jeoffrey N.L. Schouten, Harry L.A. Janssen, Edith M. Koehler, Pavel Taimr, Frank W.G. Leebeek |
| المساهمون: | Gastroenterology & Hepatology, Public Health, Hematology, Epidemiology |
| المصدر: | Hepatology, 63(1), 138-147. John Wiley & Sons Ltd. |
| بيانات النشر: | John Wiley & Sons Ltd., 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Liver Cirrhosis, Male, medicine.medical_specialty, Population, Context (language use), Gastroenterology, Diabetes Complications, 03 medical and health sciences, Rotterdam Study, 0302 clinical medicine, SDG 3 - Good Health and Well-being, Internal medicine, medicine, Humans, Prospective Studies, education, Aged, education.field_of_study, Hepatology, business.industry, Odds ratio, Middle Aged, medicine.disease, Confidence interval, Surgery, Fatty Liver, Cross-Sectional Studies, 030220 oncology & carcinogenesis, Cohort, Female, 030211 gastroenterology & hepatology, Public Health, Steatosis, Transient elastography, business |
| الوصف: | Given that little is known about the prevalence of, and factors associated with, liver fibrosis in the general population, we aimed to investigate this in a large, well-characterized cohort by means of transient elastography (TE). This study was part of the Rotterdam Study, a population-based study among individuals 45 years. All participants underwent abdominal ultrasound and TE. Liver stiffness measurement (LSM) 8.0 kilopascals (kPa) was used as a cutoff suggesting clinically relevant fibrosis. Of 3,041 participants (age, 66.0 +/- 7.6 years) with reliable LSM, 169 (5.6%) participants had LSM 8.0 kPa. Age (odds ratio [OR]: 2.40; 95% confidence interval [CI]: 1.72-3.36; P80 years. Participants with both DM and steatosis had the highest probabilities of LSM 8.0 kPa (overall probability: 17.2% [12.5-23.4]; this probability did not increase with age [P=0.8]). Conclusion: In this large population-based study of older adults, LSM 8.0 kPa, suggestive of clinically relevant fibrosis, was present in 5.6% and was strongly associated with steatosis and DM. In the context of an aging population and an increased prevalence of DM and obesity, this study illustrates that liver fibrosis may become a more prominent public health issue in the near future. (Hepatology 2016;63:138-147) |
| وصف الملف: | application/pdf |
| تدمد: | 1527-3350 0270-9139 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cba08e441020426c4f0bb52f02daa0aTest https://pure.eur.nl/en/publications/291280d9-5246-438c-bbd0-a7f13b1b62e2Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....8cba08e441020426c4f0bb52f02daa0a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15273350 02709139 |
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