Global temporal changes in the proportion of children with advanced disease at the start of combination antiretroviral therapy in an era of changing criteria for treatment initiation

التفاصيل البيبلوغرافية
العنوان:	Global temporal changes in the proportion of children with advanced disease at the start of combination antiretroviral therapy in an era of changing criteria for treatment initiation
المؤلفون:	Panayidou, K, Davies, M-A, Anderegg, N, Egger, M, Fatti, G, Vinikoor, M, Sawry, S, Ehmer, J, Eley, B, Phiri, S, Technau, K-G, Chimbetete, C, Rabie, H, Boulle, A, Tanser, F, Wood, R, Wools-Kaloustian, K, Vreeman, R, Oyaro, P, Ayaya, S, Nakigozi, G, Musick, B, Yiannoutsos, C, Amorissani-Folquet, M, Takassi, E, Sylla, M, Renner, L, Malateste, K, Desmonde, S, Leroy, V, Kurniati, N, Hansudewechakul, R, Lam, VN, Ly, PS, Khanh, HT, Kariminia, A, Sohn, AH, Edmonds, A, Yumo, HA, Dusingize, JC, Yotebieng, M, Judd, A, Rojo, P, Smit, C, Grabar, S, Warszwarski, J, Chene, G, Raban, D, Patel, K, Seage, GR, Van Dyke, RB, Oleske, J, Williams, PL, Abzug, MJ, Succi, R, Machado, DM, Pinto, J, Rouzier, V, Luque, M, Mejia, F, Khol, V, Tucker, J, Kumarasamy, N, Saghayam, S, Chandrasekaran, E, Wati, DK, Vedaswari, D, Malino, IY, Muktiarti, D, Fong, SM, Lim, M, Daut, F, Yusoff, NKN, Mohamad, P, Mohamed, TJ, Drawis, MR, Nallusamy, R, Chan, KC, Sudjaritruk, T, Sirisanthana, V, Aurpibul, L, Oberdorfer, P, Denjanta, S, Watanaporn, S, Kongphonoi, A, Lumbiganon, P, Kosalaraksa, P, Tharnprisan, P, Udomphanit, T, Jourdain, G, Puthanakit, T, Anugulruengkitt, S, Phadungphon, C, Chokephaibulkit, K, Lapphra, K, Phongsamart, W, Sricharoenchai, S, Truong, KH, Du, QT, Nguyen, CH, Do, VC, Ha, TM, An, VT, Nguyen, LV, Khu, DTK, Pham, AN, Nguyen, LT, Le, ON, Ross, JL, Sethaputra, C, Law, MG, Cahn, P, Cesar, C, Fink, V, Sued, O, Dell'Isola, E, Perez, H, Valiente, J, Yamamoto, C, Grinsztejn, B, Veloso, V, Luz, P, de Boni, R, Wagner, SC, Friedman, R, Moreira, R, Ferreira, F, Maia, M, de Menezes Succi, RC, Maria Machado, D, Barbosa Gouvea, ADF, Wolff, M, Cortes, C, Rodriguez, MF, Allendes, G, William Pape, J, Marcelin, A, Perodin, C, Tulio Luque, M, Padgett, D, Sierra Madero, J, Crabtree Ramirez, B, Belaunzaran, P, Caro Vega, Y, Gotuzzo, E, Carriquiry, G, McGowan, CC, Shepherd, BE, Sterling, T, Jayathilake, K, Person, AK, Rebeiro, PF, Giganti, M, Castilho, J, Duda, SN, Maruri, F, Vansell, H, Pelagie, N, Gateretse, P, Munezero, J, Nitereka, V, Niyongabo, T, Twizere, C, Bukuru, H, Nahimana, T, Biziragusenyuka, J, Manyundo, RS, Atsu, K, Mbuh, T, Ajeh, R, Benwi, M, Dzudie, A, Mbuh, A, Ngamani, ML, Nkome, V, Amadou, D, Ngassam, E, Yone, EWP, Ewanoge, AN, Fuhngwa, N, Moki, C, Akele, C, Kitetele, F, Lelo, P, Tabala, M, Okitolonda, EW, Wenzi, L, Diafouka, M, Ekat, MH, Nsonde, DM, Mafou, A, Ntarambirwa, F, Tuyishimire, Y, Hakizimana, T, Ayinkamiye, J, Mukantwali, S, Kayitesi, H, Uwamahoro, O, Habumuremyi, V, Mukamana, J, Kubwimana, G, Mugenzi, P, Muhoza, B, Munyaneza, A, Ndahiro, E, Nyiransabimana, D, Sinayobye, JD, Sugira, V, Benekigeri, C, Mbaraga, G, Adedimeji, A, Anastos, K, Dilorenzo, M, Murchison, L, Ross, J, Addison, D, Baker, M, Brazier, E, Jones, H, Kelvin, E, Kulkarni, S, Nash, D, Tymejczyk, O, Elul, B, Cai, X, Hoover, D, Kim, H-Y, Li, C, Shi, Q, Lancaster, K, Kuniholm, M, Parcesepe, A, Duda, S, Kimmel, A, McNairy, M, Diero, L, Bukusi, E, Ssali, J, Nalugoda, F, Somi, GR, Lyamuya, RE, Ngonyani, K, Lugina, E, Urassa, M, Michael, D, Zannou, MD, Poda, A, Sarfo, FS, Messou, E, Chenal, H, Minga, KA, Bissagnene, E, Tanon, A, Seydi, M, Patassi, AA, Koumakpai-Adeothy, SA, Renner, LA, N'Gbeche, SM, Bosse, CA, Kouakou, K, Folquet, MA, Eboua, FT, Traore, FD, Dabis, F, Arrive, E, Balestre, E, Becquet, R, Bernard, C, Arikawa, SC, Doring, A, Jaquet, A, Rabourdin, E, Tiendrebeogo, T, Jesson, J, Ekouevi, DK, Azani, J-C, Coffie, P, Gnepa, G, Kouadio, CGK, Tchounga, B, Maartens, G, von Lettow, M, Muhairwe, J, Jores, A, Kamenova, K, Fox, MP, Prozesky, H, Zangerle, R, Touloumi, G, Warszawski, J, Meyer, L, Krause, MM, Ghosn, J, Leport, C, Wittkop, L, Reiss, P, Wit, F, Prins, M, Bucher, H, Gibb, D, Faetkenheuer, G, Del Amo, J, Obel, N, Thorne, C, Mocroft, A, Kirk, O, Stephan, C, Perez-Hoyos, S, Hamouda, O, Bartmeyer, B, Chkhartishvili, N, Noguera-Julian, A, Antinori, A, Monforte, AD, Brockmeyer, N, Prieto, L, Rojo Conejo, P, Soriano-Arandes, A, Battegay, M, Kouyos, R, Mussini, C, Tookey, P, Casabona, J, Miro, JM, Castagna, A, Konopnick, D, Goetghebuer, T, Sonnerborg, A, Torti, C, Sabin, C, Teira, R, Garrido, M, Haerry, D, de Wit, S, Costagliola, D, d'Arminio-Monforte, A, del Amo, J, Raben, D, Conejo, PR, Barger, D, Schwimmer, C, Termote, M, Campbell, M, Frederiksen, CM, Friis-Moller, N, Kjaer, J, Brandt, RS, Berenguer, J, Bohlius, J, Bouteloup, V, Cozzi-Lepri, A, Dorrucci, M, Dunn, D, Furrer, H, Guiguet, M, Lambotte, O, Lodi, S, Matheron, S, Ma Miro, J, Monge, S, Nakagawa, F, Paredes, R, Phillips, A, Puoti, M, Rohner, E, Schomaker, M, Sterne, J, Thiebaut, R, van der Valk, M, Hazra, R, Heckman, B, O'gara, E, Siminski, S
المصدر:	Journal of the International AIDS Society , 21 (11) , Article e25200. (2018)
بيانات النشر:	JOHN WILEY & SONS LTD
سنة النشر:	2018
المجموعة:	University College London: UCL Discovery
مصطلحات موضوعية:	antiretroviral therapy, advanced HIV disease, CD4 cell count, WHO guidelines, sub-Saharan Africa, North America, Caribbean, Central and South America, Europe, Asia
الوصف:	INTRODUCTION: The CD4 cell count and percent at initiation of combination antiretroviral therapy (cART) are measures of advanced HIV disease and thus are important indicators of programme performance for children living with HIV. In particular, World Health Organization (WHO) 2017 guidelines on advanced HIV disease noted that >80% of children aged <5 years started cART with WHO Stage 3 or 4 disease or severe immune suppression. We compared temporal trends in CD4 measures at cART start in children from low‐, middle‐ and high‐income countries, and examined the effect of WHO treatment initiation guidelines on reducing the proportion of children initiating cART with advanced disease. METHODS: We included children aged <16 years from the International Epidemiology Databases to Evaluate acquired immunodeficiency syndrome (AIDS) (IeDEA) Collaboration (Caribbean, Central and South America, Asia‐Pacific, and West, Central, East and Southern Africa), the Collaboration of Observational HIV Epidemiological Research in Europe (COHERE), the North American Pediatric HIV/AIDS Cohort Study (PHACS) and International Maternal Pediatric Adolescent AIDS Clinical Trials (IMPAACT) 219C study. Severe immunodeficiency was defined using WHO guidelines. We used generalized weighted additive mixed effect models to analyse temporal trends in CD4 measurements and piecewise regression to examine the impact of 2006 and 2010 WHO cART initiation guidelines. RESULTS: We included 52,153 children from fourteen low‐, eight lower middle‐, five upper middle‐ and five high‐income countries. From 2004 to 2013, the estimated percentage of children starting cART with severe immunodeficiency declined from 70% to 42% (low‐income), 67% to 64% (lower middle‐income) and 61% to 43% (upper middle‐income countries). In high‐income countries, severe immunodeficiency at cART initiation declined from 45% (1996) to 14% (2012). There were annual decreases in the percentage of children with severe immunodeficiency at cART initiation after the WHO guidelines ...
نوع الوثيقة:	article in journal/newspaper
وصف الملف:	text
اللغة:	English
العلاقة:	https://discovery.ucl.ac.uk/id/eprint/10064903/1/Panayidou_et_al-2018-Journal_of_the_International_AIDS_Society.pdfTest; https://discovery.ucl.ac.uk/id/eprint/10064903Test/
الإتاحة:	https://discovery.ucl.ac.uk/id/eprint/10064903/1/Panayidou_et_al-2018-Journal_of_the_International_AIDS_Society.pdfTest https://discovery.ucl.ac.uk/id/eprint/10064903Test/
حقوق:	open
رقم الانضمام:	edsbas.C827BF69
قاعدة البيانات:	BASE

View record in BASE

الوصف
الوصف غير متاح.