دورية أكاديمية
Parent of origin effects in attention/deficit hyperactivity disorder (ADHD): analysis of data from the international multicenter ADHD genetics (IMAGE) program.
| العنوان: | Parent of origin effects in attention/deficit hyperactivity disorder (ADHD): analysis of data from the international multicenter ADHD genetics (IMAGE) program. |
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| المؤلفون: | Anney, R., Hawi, Z., Sheehan, K., Mulligan, A., Pinto, C., Brookes, K., Xu, X., Zhou, K., Franke, B., Buitelaar, J.K., Vermeulen, H.H.M., Banaschewski, T., Sonuga-Barke, E.J.S., Ebstein, R.P., Manor, I., Miranda, A., Mulas, F., Oades, R.D., Roeyers, H., Lambregts-Rommelse, N.N.J., Rothenberger, A., Sergeant, J.A., Steinhausen, H.C., Taylor, E., Thompson, M., Asherson, P., Faraone, S.V., Gill, M. |
| المصدر: | American Journal of Medical Genetics. Part B : Neuropsychiatric Genetics, 147B, 8, pp. 1495-500 |
| بيانات النشر: | John Wiley & Sons Wiley-Blackwell |
| سنة النشر: | 2008 |
| مصطلحات موضوعية: | DCN 1: Perception and Action, DCN 2: Functional Neurogenomics, DCN 3: Neuroinformatics, IGMD 3: Genomic disorders and inherited multi-system disorders, NCEBP 1: Molecular epidemiology, NCEBP 9: Mental health, NCMLS 6: Genetics and epigenetic pathways of disease, ONCOL 3: Translational research, UMCN 3.2: Cognitive neurosciences, UMCN 5.1: Genetic defects of metabolism, UMCN 5.2: Endocrinology and reproduction, psy |
| الوصف: | Contains fulltext : 71540.pdf (Publisher’s version ) (Closed access) ; There are conflicting reports suggesting that the parental origin of transmitted risk alleles may play a role in the etiology of attention deficit/hyperactivity disorder (ADHD). A recent report by Hawi and colleagues observed a generalized paternal over-transmission of alleles associated with ADHD. This was not replicated in more recent studies. Using data from a large multicenter study we examined the overall and gene-specific parent of origin effect in 554 independent SNPs across 47 genes. Transmission disequilibrium and explicit parent of origin test were performed using PLINK. Overall parent of origin effect was tested by Chi-square. There was no overall parent of origin effect in the IMAGE sample (chi(1)(2) = 1.82, P = 0.117). Five markers in three genes, DDC, TPH2, and SLC6A2 showed nominal association (P < 0.01) with ADHD combined subtype when restricted to maternal or paternal transmission only. Following the initial report by Hawi and co-workers three studies, including this one, found no evidence to support an overall parent of origin effect for markers associated with ADHD. We cannot however, exclude gene-specific parent of origin effect in the etiology ADHD. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| العلاقة: | http://hdl.handle.net/2066/71540Test |
| الإتاحة: | http://hdl.handle.net/2066/71540Test |
| حقوق: | undefined |
| رقم الانضمام: | edsbas.7EC7E5FB |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |