التفاصيل البيبلوغرافية
| العنوان: |
Treatment-Specific Hippocampal Subfield Volume Changes With Antidepressant Medication or Cognitive-Behavior Therapy in Treatment-Naive Depression. |
| المؤلفون: |
Tai, Hua-Hsin, Cha, Jungho, Vedaei, Faezeh, Dunlop, Boadie W, Craighead, W Edward, Mayberg, Helen S, Choi, Ki Sueng |
| المصدر: |
Department of Neuroscience Faculty Papers |
| بيانات النشر: |
Jefferson Digital Commons |
| سنة النشر: |
2021 |
| مصطلحات موضوعية: |
Thomas Jefferson University, adult, age, amygdala, Article, brain atrophy, brain size, chronicity, cognitive behavioral therapy, controlled study, correlation analysis, dentate gyrus granular layer, dentate hilus, DSM-IV, female, gender, Hamilton Depression Rating Scale, hippocampal CA1 region, hippocampal CA3 region, hippocampal fimbria, hippocampus, human, image analysis, intermethod comparison, major clinical study, major depression, male, multimodal imaging, nerve cell differentiation, nerve cell plasticity |
| الوصف: |
Background: Hippocampal atrophy has been consistently reported in major depressive disorder with more recent focus on subfields. However, literature on hippocampal volume changes after antidepressant treatment has been limited. The first-line treatments for depression include antidepressant medication (ADM) or cognitive-behavior therapy (CBT). To understand the differential effects of CBT and ADM on the hippocampus, we investigated the volume alterations of hippocampal subfields with treatment, outcome, and chronicity in treatment-naïve depression patients. Methods: Treatment-naïve depressed patients from the PReDICT study were included in this analysis. A total of 172 patients who completed 12 weeks of randomized treatment with CBT (n = 45) or ADM (n = 127) were included for hippocampal subfield volume analysis. Forty healthy controls were also included for the baseline comparison. Freesurfer 6.0 was used to segment 26 hippocampal substructures and bilateral whole hippocampus from baseline and week 12 structural MRI scans. A generalized linear model with covariates of age and gender was used for group statistical tests. A linear mixed model for the repeated measures with covariates of age and gender was used to examine volumetric changes over time and the contributing effects of treatment type, outcome, and illness chronicity. Results: Of the 172 patients, 85 achieved remission (63/127 ADM, 22/45 CBT). MDD patients showed smaller baseline volumes than healthy controls in CA1, CA3, CA4, parasubiculum, GC-ML-DG, Hippocampal Amygdala Transition Area (HATA), and fimbria. Over 12 weeks of treatment, further declines in the volumes of CA1, fimbria, subiculum, and HATA were observed regardless of treatment type or outcome. CBT remitters, but not ADM remitters, showed volume reduction in the right hippocampal tail. Unlike ADM remitters, ADM non-responders had a decline in volume in the bilateral hippocampal tails. Baseline volume of left presubiculum (regardless of treatment type) and right fimbria and HATA in CBT . |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| العلاقة: |
https://jdc.jefferson.edu/department_neuroscience/60Test |
| الإتاحة: |
https://jdc.jefferson.edu/department_neuroscience/60Test |
| حقوق: |
undefined |
| رقم الانضمام: |
edsbas.33B037EF |
| قاعدة البيانات: |
BASE |
