دورية أكاديمية
Comparison of Oral Montelukast and Intranasal Fluticasone in Patients with Asthma and Allergic Rhinitis
| العنوان: | Comparison of Oral Montelukast and Intranasal Fluticasone in Patients with Asthma and Allergic Rhinitis |
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| المؤلفون: | Apar Jindal, Subramanian Suriyan, Suresh Sagadevan, Meenakshi Narasimhan, Aruna Shanmuganathan, Viswambhar Vallabhaneni, Ragulan Rajalingam |
| المصدر: | Journal of Clinical and Diagnostic Research, Vol 10, Iss 8, Pp OC06-OC10 (2016) |
| بيانات النشر: | JCDR Research and Publications Private Limited, 2016. |
| سنة النشر: | 2016 |
| المجموعة: | LCC:Medicine |
| مصطلحات موضوعية: | intra nasal steroids, leukotriene antagonists, nasobronchial allergy, Medicine |
| الوصف: | Introduction: Even though the links between upper and lower airway had been of interest to clinicians since long back, it has not attracted the attention of the researchers till recent past. But the evidence is still far from conclusive, due to limited number of randomized controlled trials available on subjects with concomitant allergic rhinitis and asthma. This gap in the knowledge is even more conspicuous in Indian population. Aim: The current study is conducted with an objective of comparing the efficacy and tolerability of intranasal Fluticasone and oral Montelukast in treatment of allergic rhinitis and bronchial asthma. Materials and Methods: The study was a prospective randomized, single blinded, comparative, parallel group study, with two intervention groups conducted in a tertiary teaching hospital in Chennai, Southern India. One hundred and twenty patients diagnosed with concomitant diagnosis of allergic rhinitis and bronchial asthma was randomly allocated to either Fluticasone propionate aqueous nasal spray or oral Montelukast group. Results: Out of total 120 subjects recruited, 108 subjects were included in the final analysis. The mean reduction in asthma and rhinitis symptom scores and improvement in PEFR was higher for Group A, compared to Group B during all the follow-up periods. No statistically significant difference was observed in proportion of subjects reporting exacerbations in the current study. Both the treatments were well tolerated. Conclusion: Addition of intranasal Fluticasone propionate to Salmeterol plus Fluticasone is beneficial in improving asthma control, allergic rhinitis control and lung functions as compared to oral Montelukast. Thereby the use of intranasal Fluticasone Propionate in comparison to oral Montelukast in control of Allergic Rhinitis is justified as per the significant improvement in outcome measures. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2249-782X 0973-709X |
| العلاقة: | https://jcdr.net/articles/PDF/8268/20741_CETest(RA1)_F(T)_PF1(ROAK)_PFA(AK)_PF2(PAG).pdf; https://doaj.org/toc/2249-782XTest; https://doaj.org/toc/0973-709XTest |
| DOI: | 10.7860/JCDR/2016/20741.8268 |
| الوصول الحر: | https://doaj.org/article/ea5536a2aa9042f1813ebf67286dc733Test |
| رقم الانضمام: | edsdoj.5536a2aa9042f1813ebf67286dc733 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 2249782X 0973709X |
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| DOI: | 10.7860/JCDR/2016/20741.8268 |