Peripheral Blood Neutrophil-to-lymphocyte Ratio as a Predictor of Functional Outcomes in Patients with Hemorrhagic Stroke
| العنوان: | Peripheral Blood Neutrophil-to-lymphocyte Ratio as a Predictor of Functional Outcomes in Patients with Hemorrhagic Stroke |
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| المؤلفون: | Sethu, Babu, Mathew, Pulicken, Arun K, Thazhathuveedu |
| المصدر: | Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine |
| بيانات النشر: | Jaypee Brothers Medical Publishing, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Modified Rankin scale, fungi, Original Article, Intracranial hemorrhage, The ICH score, cardiovascular diseases, Hemorrhagic stroke, Critical Care and Intensive Care Medicine, Functional outcomes, Neutrophil-to-lymphocyte ratio |
| الوصف: | Background Peripheral blood neutrophil-to-lymphocyte ratio (NLR) has recently emerged as a prognostic biomarker in many disease states. The aim of this study was to evaluate the diagnostic utility of NLR to predict poor functional outcomes in patients with hemorrhagic stroke and to compare it with the intracranial hemorrhage (ICH) score. Materials and methods Patients who presented to the emergency department with clinical features suggestive of stroke were evaluated with computed tomography (CT) brain to identify ICH. The ICH scores and NLR were estimated at the time of admission. Modified Rankin Scale (mRS) score equal to or greater than 3 at 90 days was used to define poor functional outcomes (major disability or death). Receiver operating characteristic (ROC) curve was plotted with NLR and the ICH score to analyze and compare their discriminative ability to predict poor functional outcomes. Results A total of 158 patients were recruited for the study. One hundred and seven patients were found to have poor functional outcomes as per their mRS score at 90 days. The mean NLR and the ICH scores at presentation were significantly higher for the poor outcome group (6.57 and 2.83) compared to the good outcome group (2.75 and 1.49). The ROC analysis revealed that both NLR and the ICH scores were good predictors of functional outcomes at 90 days with area under the curve (AUC) of 0.814 and 0.819, respectively. The sensitivity and specificity of NLR were 84 and 66.3% and those of the ICH score were 66.7 and 78.3% to predict poor functional outcomes. Conclusion In patients with hemorrhagic stroke, NLR at admission is a good predictor of functional outcomes at 90 days. When compared to the ICH score, NLR is more sensitive but less specific in predicting poor functional outcomes. How to cite this article Babu S, Pulicken M, Thazhathuveedu AK. Peripheral Blood Neutrophil-to-lymphocyte Ratio as a Predictor of Functional Outcomes in Patients with Hemorrhagic Stroke. Indian J Crit Care Med 2022;26(1):18–22. |
| تدمد: | 1998-359X 0972-5229 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c9b79013dda9dbe411c44bed74f212bTest https://doi.org/10.5005/jp-journals-10071-24074Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....9c9b79013dda9dbe411c44bed74f212b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1998359X 09725229 |
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