Frequencies of PrP Genotypes in Meat Breeds of Japanese Sheep and Trail of Selective Breeding in Experimental Sheep Flock
| العنوان: | Frequencies of PrP Genotypes in Meat Breeds of Japanese Sheep and Trail of Selective Breeding in Experimental Sheep Flock |
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| المؤلفون: | Junko Maeda, Hidefumi Furuoka, Tetsuro Togari, Aya Kurokawa, Motohiro Horiuchi, Jiro Ohara, Naotaka Ishiguro |
| المصدر: | Journal of Veterinary Medical Science. 69:1325-1329 |
| بيانات النشر: | Japanese Society of Veterinary Science, 2007. |
| سنة النشر: | 2007 |
| مصطلحات موضوعية: | Male, Veterinary medicine, Sheep, Transmissible spongiform encephalopathy, Genotype, General Veterinary, biology, Prions, biology.animal_breed, Haplotype, Scrapie, Breeding, medicine.disease, Selective breeding, Breed, Sheep flock, Animal science, Japan, medicine, Animals, Suffolk sheep, Female |
| الوصف: | The selection of sheep with scrapie-resistant PrP genotypes is one of the control measures for transmissible spongiform encephalopathies in ruminants. In this study, we investigated the frequencies of PrP genotypes in meat breeds in Japan. The nationwide surveillance revealed that nearly half of the Suffolk sheep, a major meat breed in Japan, carried scrapie-susceptible AQ/AQ and AQ/VQ genotypes. In addition, the VQ haplotype, which confers high susceptibility to scrapie within sheep, was also found in Poll Dorset sheep. A trial of selective breeding using sires with scrapie-resistant PrP genotypes AQ/AR and AR/AR could raise the ratio of scrapie-resistant sheep from less than 50% to 80% within 3 years. However, the use of sires with the AR/AR genotype and the selection of ewes would be required to achieve a higher ratio of scrapie-resistant sheep. |
| تدمد: | 1347-7439 0916-7250 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::422dce2795751c369b023f2746d488ebTest https://doi.org/10.1292/jvms.69.1325Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....422dce2795751c369b023f2746d488eb |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13477439 09167250 |
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