Primary Hyperparathyroidism Associatiated with Aldosterone-Producing Adrenocortical Adenoma and Breast Cancer: Relation to MEN1 Gene
| العنوان: | Primary Hyperparathyroidism Associatiated with Aldosterone-Producing Adrenocortical Adenoma and Breast Cancer: Relation to MEN1 Gene |
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| المؤلفون: | Toshimitsu Horiuchi, Miyuki Ishibashi, Ken Yamaguchi, Hiroshi Miyakawa, Toshihiko Tsukada, Takao Obara, Reiko Tanaka, Munehiro Honda, Tohru Yamaji |
| المصدر: | Internal Medicine. 43:310-314 |
| بيانات النشر: | Japanese Society of Internal Medicine, 2004. |
| سنة النشر: | 2004 |
| مصطلحات موضوعية: | Adenoma, Adult, endocrine system, Pathology, medicine.medical_specialty, endocrine system diseases, DNA Mutational Analysis, Loss of Heterozygosity, Breast Neoplasms, Gastroenterology, Adrenocortical adenoma, Breast cancer, Proto-Oncogene Proteins, Internal medicine, Hyperaldosteronism, Multiple Endocrine Neoplasia Type 1, Internal Medicine, Humans, Medicine, Genes, Tumor Suppressor, Aldosterone, Germ-Line Mutation, Parathyroid adenoma, Hyperparathyroidism, Polymorphism, Genetic, business.industry, Sequence Analysis, DNA, General Medicine, medicine.disease, Adrenal Cortex Neoplasms, Parathyroid Neoplasms, medicine.anatomical_structure, Adrenocortical Adenoma, Female, Parathyroid gland, business, Primary hyperparathyroidism |
| الوصف: | A rare case of primary hyperparathyroidism associated with primary aldosteronism and breast cancer is reported. A 44-year-old woman was admitted to our hospital to undergo surgical removal of breast cancer. She had hypertension with low serum potassium, and slightly but significantly elevated serum calcium levels. Further studies demonstrated an enlarged left superior parathyroid gland and a left aldosterone-producing adrenocortical adenoma. Blood pressure was controlled with spironolactone and nifedipine, and left mastectomy was done for breast cancer. The pathological diagnosis was scirrhous breast carcinoma. Although the postoperative course was uneventful, her serum calcium gradually and progressively rose to higher levels. Left superior parathyroidectomy and left adrenalectomy were then performed simultaneously. The pathological diagnoses of the resected parathyroid gland and adrenal gland were parathyroid chief cell adenoma and adrenocortical adenoma with hyperplasia of zona glomerulosa, respectively. To clarify if the occurence of these tumors may be related to MEN1 gene mutations, we analyzed MEN1 gene in this patient, and found a loss of heterozygosity of the MEN1 locus in the parathyroid adenoma and breast cancer. Thus, we conclude that an alteration of the MEN1 gene and/or another tumor suppressor gene located at the MEN1 locus on chromosome 11q13 may be responsible for the development of parathyroid adenoma and breast cancer in our patient suggesting that the clinical spectrum of MEN1 might include breast cancer. In addition, serum calcium should be interpreted with caution in primary aldosteronism, because hypercalcemia may be masked in the presence of aldosterone excess. |
| تدمد: | 1349-7235 0918-2918 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a5bdd1191d3e614181938cfe7064996Test https://doi.org/10.2169/internalmedicine.43.310Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....6a5bdd1191d3e614181938cfe7064996 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13497235 09182918 |
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