Multiple Endocrine Neoplasia Type I and Cushing's Syndrome Due to an Aggressive ACTH Producing Thymic Carcinoid
| العنوان: | Multiple Endocrine Neoplasia Type I and Cushing's Syndrome Due to an Aggressive ACTH Producing Thymic Carcinoid |
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| المؤلفون: | Yoshifumi Hirooka, Yoshinobu Hattori, Kazuhiro Yoshikawa, Harumichi Kato, Kazuo Otake, Catharina Larsson, Junko Takagi, Munehiko Morishita, Naoki Nakao, Tsuyoshi Nogimori, Hiroshi Ikeda |
| المصدر: | Internal Medicine. 45:81-86 |
| بيانات النشر: | Japanese Society of Internal Medicine, 2006. |
| سنة النشر: | 2006 |
| مصطلحات موضوعية: | Adult, Male, endocrine system, medicine.medical_specialty, Pathology, Antineoplastic Agents, Hormonal, endocrine system diseases, Nonsense mutation, Carcinoid Tumor, Octreotide, Germline, Fatal Outcome, Adrenocorticotropic Hormone, Pituitary adenoma, Internal medicine, Antineoplastic Combined Chemotherapy Protocols, Multiple Endocrine Neoplasia Type 1, Internal Medicine, medicine, Humans, Multiple endocrine neoplasia, Cushing Syndrome, Germ-Line Mutation, S syndrome, biology, business.industry, Thymic Carcinoid, Chromogranin A, Thymus Neoplasms, General Medicine, Thymectomy, medicine.disease, Combined Modality Therapy, digestive system diseases, ACTH Syndrome, Ectopic, Endocrinology, biology.protein, Radiotherapy, Adjuvant, business, Primary hyperparathyroidism |
| الوصف: | Thymic carcinoid in multiple endocrine neoplasia type 1 (MEN 1) is previously reported as a non-ACTH producing tumor. The present case is a 39-year-old man with mortal outcome from thymic carcinoid and Cushing's syndrome with high plasma ACTH. The symptom was first observed at age 29 and was relieved after extended thymectomy, with reduction of ACTH level. The tumor was positive for ACTH, Grimelius silver staining and Chromogranin A. The finding of primary hyperparathyroidism, pituitary adenoma, and a novel germline nonsense mutation (W423X) established the diagnosis of MEN 1. Cushing's syndrome due to ACTH producing thymic carcinoid should be also considered as one phenotype of the MEN 1 spectrum. |
| تدمد: | 1349-7235 0918-2918 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f489e33a0ee4511a03f63e304a1fcd35Test https://doi.org/10.2169/internalmedicine.45.1427Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....f489e33a0ee4511a03f63e304a1fcd35 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13497235 09182918 |
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