Durvalumab-associated Late-onset Myocarditis Successfully Treated with Corticosteroid Therapy
| العنوان: | Durvalumab-associated Late-onset Myocarditis Successfully Treated with Corticosteroid Therapy |
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| المؤلفون: | Tomoki Maetani, Toka Hamaguchi, Satoshi Marumo, Takafumi Nishimura, Motonari Fukui |
| المصدر: | Internal Medicine. 61:527-531 |
| بيانات النشر: | Japanese Society of Internal Medicine, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Lung Neoplasms, Durvalumab, Myocarditis, Late onset, Adrenal Cortex Hormones, Carcinoma, Non-Small-Cell Lung, Internal Medicine, Humans, Medicine, Exertion, Adverse effect, Lung cancer, Aged, medicine.diagnostic_test, business.industry, Antibodies, Monoclonal, Magnetic resonance imaging, Chemoradiotherapy, General Medicine, medicine.disease, Corticosteroid therapy, Radiology, business |
| الوصف: | We herein report a 66-year-old man with locally advanced non-small-cell lung cancer (NSCLC) who developed durvalumab-associated myocarditis. The patient underwent durvalumab administration every two weeks following concurrent chemoradiotherapy (CCRT), without any adverse events or apparent disease progression. He presented with fatigue and dyspnea on exertion seven months after the first administration. Myocarditis was suspected based on laboratory data, an electrocardiogram, echocardiography, and magnetic resonance imaging findings. The definitive diagnosis was confirmed by a myocardial biopsy. Myocarditis was alleviated by cessation of durvalumab and corticosteroid therapy. This is a noteworthy case to describe late-onset myocarditis following the administration of durvalumab for NSCLC. |
| تدمد: | 1349-7235 0918-2918 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7769a7bdb93b540fa08e9db2ea9b748fTest https://doi.org/10.2169/internalmedicine.7644-21Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....7769a7bdb93b540fa08e9db2ea9b748f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13497235 09182918 |
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