Comparison of the Effectiveness of Pharmacological Treatments for Patients with Chronic Low Back Pain: A Nationwide, Multicenter Study in Japan
| العنوان: | Comparison of the Effectiveness of Pharmacological Treatments for Patients with Chronic Low Back Pain: A Nationwide, Multicenter Study in Japan |
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| المؤلفون: | Hiroshi Yamada, Hideki Murakami, Mamoru Kawakami, Munehito Yoshida, Naohisa Miyakoshi, Hirotaka Haro, Tomoyuki Takura, Gen Inoue, Masashi Yamazaki, Daijiro Kabata, Motoki Iwasaki, Toshihiko Yamashita, Manabu Ito, Ayumi Shintani, Kazuo Yonenobu, Toshihiko Taguchi, Hiroshi Taneichi, Takashi Kaito, Yukihiro Matsuyama, Kotaro Nishida, Shiro Imagama, Seiji Ohtori, Kazuhisa Takahashi, Joji Mochida |
| المصدر: | Spine Surgery and Related Research Spine Surgery and Related Research, Vol 5, Iss 4, Pp 252-263 (2021) |
| بيانات النشر: | Japanese Society for Spine Surgery and Related Research, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | medicine.medical_specialty, RD1-811, business.industry, Visual analogue scale, effectiveness, Loxoprofen, humanities, Acetaminophen, pharmacological treatment, Internal medicine, Orthopedic surgery, chronic low back pain, analgesics, medicine, Celecoxib, Back pain, Original Article, Orthopedics and Sports Medicine, Surgery, Neurology (clinical), Tramadol, medicine.symptom, business, Prospective cohort study, medicine.drug |
| الوصف: | Introduction: Chronic low back pain (CLBP) is a leading cause of disability, yet there is limited high-quality evidence to identify the most suitable pharmacological therapy. The purpose of this Japanese nationwide, multicenter, prospective study was to compare the effectiveness of four representative drug therapies―acetaminophen, celecoxib, loxoprofen, and a tramadol and acetaminophen (T+A) combination drug―to establish evidence for a drug of choice for CLBP. Methods: Patients with CLBP (N=471) received one of the four treatments and were evaluated, prospectively and comprehensively, once every month for six months using a visual analog scale (VAS) for LBP, the Japanese Orthopedic Association (JOA) score, the JOA Back Pain Evaluation Questionnaire (JOABPEQ), the Roland-Morris Disability Questionnaire (RDQ), the EuroQol five-dimensions three-levels (EQ-5D-3L), and the Short Form-8 item health survey (SF-8). We conducted multivariable linear regression analyses of the four drugs at 1 and 6 months after drug allocation. Differences with P |
| تدمد: | 2432-261X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87edc57c2222f979b00623db09885d91Test https://doi.org/10.22603/ssrr.2020-0083Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....87edc57c2222f979b00623db09885d91 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 2432261X |
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