Clinical trial of autologous adipose tissue-derived regenerative (stem) cells therapy for exploration of its safety and efficacy
| العنوان: | Clinical trial of autologous adipose tissue-derived regenerative (stem) cells therapy for exploration of its safety and efficacy |
|---|---|
| المؤلفون: | Yoshio Sakai, Taro Yamashita, Yasuhito Imai, Oto Inoue, Kazuhide Higuchi, Tuyen Thuy Bich Ho, Soichiro Usui, Shuichi Kaneko, Yusuke Tsuchimoto, Akira Asai, Kuniaki Arai, Tatsuya Yamashita, Takashi Wada, Kenichi Yoshimura, Masao Honda, Shinya Fukunishi, Shinichiro Takashima, Kenichi Harada, Eishiro Mizukoshi, Toshinori Murayama, Masayuki Takamura, Alessandro Nasti, Akihiro Seki, Kazunori Kawaguchi |
| المصدر: | Regenerative Therapy Regenerative Therapy, Vol 18, Iss, Pp 97-101 (2021) |
| بيانات النشر: | Japanese Society for Regenerative Medicine, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, Medicine (General), medicine.medical_specialty, Cirrhosis, MSCs, mesenchymal stem cells, Adipose tissue dissociation device, NASH, non-alcoholic steatohepatitis, Biomedical Engineering, Adipose tissue, Gastroenterology, Biomaterials, Cell therapy, 03 medical and health sciences, R5-920, 0302 clinical medicine, Internal medicine, Fatty liver diseases, medicine, Adipose tissue-derived regenerative (stem) cells, Non-alcoholic steatohepatitis, QH573-671, business.industry, Fatty liver, Conductible, ADRCs, adipose tissue derived regenerative (stem) cells, medicine.disease, Clinical trial, 030104 developmental biology, PMDA, Japan Pharmaceuticals and Medical Devices Agency, Liver cirrhosis, Original Article, NAFLD, nonalcoholic fatty liver disease, Steatohepatitis, Stem cell, Cytology, business, 030217 neurology & neurosurgery, Developmental Biology |
| الوصف: | Introduction Liver cirrhosis is the ultimate condition of chronic liver diseases. Non-alcoholic steatohepatitis and fatty liver diseases are emerging in association with metabolic syndrome largely due to excess nutrition. Stromal cells of adipose tissue are enriched mesenchymal stem cells which are pluripotent and immunomodulatory, which are expected to be applied for repairing/regenerative therapy of the impaired organs. Methods We conducted the multi-institutional clinical trial (Japanese UMIN Clinical Trial Registry: UMIN000022601) of cell therapy using freshly isolated autologous adipose tissue-derived regenerative (stem) cells (ADRCs), which are obtained by the investigational trial device, adipose tissue dissociation device, for liver cirrhosis patients due to non-alcoholic steatohepatitis or fatty liver disease, to exploratory assess efficacy as well as safety of this trial. We completed treatment and 24 weeks follow-up for 7 patients. Results We observed that 6 out of 7 patients' serum albumin concentration was improved. As for prothrombin activity, 5 out of 7 patients showed improvement. No trial-related adverse events, which were serious or non-serious, was observed. Besides, no malfunction of the investigational trial device was encountered. Conclusion Thus, treatment with autologous ADRCs obtained with the investigational trial device in steatohepatitis-related cirrhosis was confirmed to be safely conductible and potentially promising for the retaining or improving the impaired hepatic reserve. |
| اللغة: | English |
| تدمد: | 2352-3204 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::498cb8601adedc4119b89a161cd23e11Test http://europepmc.org/articles/PMC8165289Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....498cb8601adedc4119b89a161cd23e11 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 23523204 |
|---|