Effects of propranolol and diltiazem on carnitine derivatives and acyl CoA in ischemic myocardium
| العنوان: | Effects of propranolol and diltiazem on carnitine derivatives and acyl CoA in ischemic myocardium |
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| المؤلفون: | Jun Kamiya, Akira Kobayashi, Noboru Yamazaki |
| المصدر: | Japanese Circulation Journal. 49:1167-1174 |
| بيانات النشر: | Japanese Circulation Society, 1985. |
| سنة النشر: | 1985 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Acute myocardial ischemia, Long chain acyl CoA, Physiology, Coronary Disease, Propranolol, Diltiazem, chemistry.chemical_compound, Acyl-CoA, Adenosine Triphosphate, Dogs, Carnitine, Internal medicine, medicine, Animals, chemistry.chemical_classification, biology, Chemistry, Myocardium, Fissipedia, Fatty acid, Arrhythmias, Cardiac, Benzazepines, biology.organism_classification, Endocrinology, Coronary occlusion, cardiovascular system, Female, Acyl Coenzyme A, Carnitine derivatives, Cardiology and Cardiovascular Medicine, Oxidation-Reduction, Adenosine triphosphate, medicine.drug |
| الوصف: | The accumulation of intermediates subsequent to impaired β-oxidation of free fatty acid (FFA) has been suggested as a cause of cellular damage in ischemic myocardium. ^ We investigated the effects of propranolol and diltiazem on carnitine metabolism in ischemic myocardium. Propranolol (0.2 mg/kg/min, i.v.) and diltiazem (0.1 mg/kg/min, i.v.) were administered for 5 min, the administration started 10 min before coronary occlusion. ECGs were continuously recorded throughout the experiment. Myocardial samples were prepared from both the non-ischemic and ischemic areas 40 min after coronary ligation. Adenosine triphosphate (ATP), free carnitine, long chain acyl carnitine and long chain acyl CoA were assayed. Propranolol reduced the decrease of ATP and the accumulation of long chain acyl CoA, induced by myocardial ischemia. Diltiazem reduced the decrease of ATP and free carnitine, and the accumulation of long chain acyl carnitine in the ischemic area. Propranolol and diltiazem significantly reduced the grade of ventricular arrhythmia. These results suggest that the protective mechanisms of propranolol and diltiazem on myocardium are based, at least in part, on their beneficial effects upon myocardial carnitine metabolism |
| وصف الملف: | application/pdf |
| تدمد: | 1347-4839 0047-1828 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aefff309619c26da6bb7d8f97aaf64efTest https://doi.org/10.1253/jcj.49.1167Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....aefff309619c26da6bb7d8f97aaf64ef |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13474839 00471828 |
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