High-Dose Granulocyte-Colony Stimulating Factor Promotes Neointimal Hyperplasia in the Early Phase and Inhibits Neointimal Hyperplasia in the Late Phase After Vascular Injury
| العنوان: | High-Dose Granulocyte-Colony Stimulating Factor Promotes Neointimal Hyperplasia in the Early Phase and Inhibits Neointimal Hyperplasia in the Late Phase After Vascular Injury |
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| المؤلفون: | Yasutoshi Omori, Yoshitaka Iso, Youichi Kobayashi, Teruko Soda, Fumiyoshi Tsunoda, Eiichi Geshi, Shinji Koba, Hiroshi Suzuki, Makoto Shoji, Takatoshi Sato, Taro Kusuyama, Takashi Katagiri |
| المصدر: | Circulation Journal. 72:1885-1893 |
| بيانات النشر: | Japanese Circulation Society, 2008. |
| سنة النشر: | 2008 |
| مصطلحات موضوعية: | Male, Neointima, medicine.medical_specialty, CD34, Antigens, CD34, Inflammation, Mice, Restenosis, Internal medicine, Granulocyte Colony-Stimulating Factor, medicine, Animals, Antigens, Ly, Progenitor cell, Cell Proliferation, Neointimal hyperplasia, Mice, Inbred BALB C, Hyperplasia, business.industry, Stem Cells, Membrane Proteins, General Medicine, medicine.disease, Bone Marrow-Derived Cell, Granulocyte colony-stimulating factor, Femoral Artery, Endocrinology, Immunology, medicine.symptom, Tunica Intima, Cardiology and Cardiovascular Medicine, business |
| الوصف: | Background Granulocyte-colony stimulating factor (G-CSF) affects injured arteries through early endothelialization. Some reports, however, have cautioned that the restenosis rate may increase after G-CSF injection. In the present study, high-dose G-CSF was administered to mice with vascular injury to clarify its effect. Methods and Results Mice were received daily subcutaneous injections of saline or a high dose (300 μg/kg) of G-CSF for 5 days after vascular injury. In the FACS analysis, CD34-/Sca-1-positive progenitor cells were more abundant in the G-CSF group (p |
| تدمد: | 1347-4820 1346-9843 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f65c52f73c6fd8bdd2e2ce28c7b90cd9Test https://doi.org/10.1253/circj.cj-07-1037Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....f65c52f73c6fd8bdd2e2ce28c7b90cd9 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13474820 13469843 |
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