Advanced Oxidation Protein Products Exacerbates Lipid Accumulation and Atherosclerosis Through Downregulation of ATP-Binding Cassette Transporter A1 and G1 Expression in Apolipoprotein E Knockout Mice
| العنوان: | Advanced Oxidation Protein Products Exacerbates Lipid Accumulation and Atherosclerosis Through Downregulation of ATP-Binding Cassette Transporter A1 and G1 Expression in Apolipoprotein E Knockout Mice |
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| المؤلفون: | Wei Xie, Xi-Long Zheng, Zhong-Cheng Mo, Ping-Ping He, Guo-Jun Zhao, Xin-Ping Ouyang, Yu-Lin Tan, Yun-Cheng Lv, Zhi-feng Long, Min Zhang, Chao-Ke Tang, Ji Xiao, Dan Liu, Feng Yao, Guo-Ping Tian, Deng-Pei Tang, Shi-Lin Tang |
| المصدر: | Circulation Journal. 78:2760-2770 |
| بيانات النشر: | Japanese Circulation Society, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Male, Apolipoprotein E, medicine.medical_specialty, Lipoproteins, Down-Regulation, Mice, Apolipoproteins E, Downregulation and upregulation, Internal medicine, medicine, Animals, ATP Binding Cassette Transporter, Subfamily G, Member 1, Mice, Knockout, biology, business.industry, Liver X receptor alpha, Lipid metabolism, General Medicine, Atherosclerosis, Lipid Metabolism, Endocrinology, Advanced Oxidation Protein Products, ABCG1, Biochemistry, ABCA1, Knockout mouse, biology.protein, ATP-Binding Cassette Transporters, lipids (amino acids, peptides, and proteins), Cardiology and Cardiovascular Medicine, business, Janus kinase, ATP Binding Cassette Transporter 1 |
| الوصف: | Background Both clinical data and basic science studies suggest that advanced oxidation protein products (AOPPs) may contribute to the progression of atherosclerosis. The aim of this study was to investigate the effects of AOPPs on ATP-binding cassette transporter (ABC) A1 and ABCG1 expression, lipid accumulation and atherosclerotic lesions in apolipoprotein E knockout (apoE-KO) mice. METHODS AND RESULTS: Male 8-week-old apoE-KO mice were fed a high-fat/high-cholesterol diet. Mice received intraperitoneal injections of AOPPs (5 mg/kg) and/or Janus Kinase (JAK) inhibitor AG-490 (5 mg/kg) once every other day for 8 weeks. As shown in our data, AOPPs increased lipid levels of plasma, and promoted advanced lesions in the aortic regions in apoE-KO mice. The ABCA1, ABCG1 and liver X receptor alpha (LXRα) expression were downregulated in apoE-KO mice treated with AOPPs, whereas the lesions in the aortas were decreased, and the ABCA1, ABCG1 and LXRα expression were upregulated in mice treated with AOPPs plus AG-490, compared to the mice treated with AOPPs only. The ABCA1 and LXRα expressions of aortas, liver and intestine were downregulated in the AOPPs group, while the expressions were upregulated in the AOPPs-plus-AG-490 group when compared to the AOPPs group. The same results can be also observed in peritoneal macrophages. Conclusions AOPPs increase accumulation of lipids and exacerbate atherosclerosis through downregulation of ABCA1 and ABCG1 expression, and the JAK-LXRα signaling pathway in apoE-KO mice. |
| تدمد: | 1347-4820 1346-9843 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0daf88f1a72fc1961a9eb5c700f8207dTest https://doi.org/10.1253/circj.cj-14-0193Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....0daf88f1a72fc1961a9eb5c700f8207d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13474820 13469843 |
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