Reverse Correlation between Urine Nitric Oxide Metabolites and Insulin Resistance in Patients with Type 2 Diabetes Mellitus
| العنوان: | Reverse Correlation between Urine Nitric Oxide Metabolites and Insulin Resistance in Patients with Type 2 Diabetes Mellitus |
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| المؤلفون: | Soichi Kurioka, Kunio Koshimura, Yoshio Murakami, Masateru Nishiki, Yuzuru Kato |
| المصدر: | Endocrine Journal. 47:77-81 |
| بيانات النشر: | Japan Endocrine Society, 2000. |
| سنة النشر: | 2000 |
| مصطلحات موضوعية: | Adult, Male, Pancreas, Artificial, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Urine, Type 2 diabetes, Artificial pancreas, Body Mass Index, Nitric oxide, chemistry.chemical_compound, Endocrinology, Insulin resistance, Reference Values, Internal medicine, Humans, Medicine, Nitrites, Aged, Nitrates, business.industry, Type 2 Diabetes Mellitus, Middle Aged, medicine.disease, Glucose, Blood pressure, Diabetes Mellitus, Type 2, chemistry, Glucose Clamp Technique, Female, Insulin Resistance, business, Body mass index |
| الوصف: | We studied the possible relationship between nitric oxide (NO) production and insulin resistance in patients with type 2 diabetes mellitus. Urine NO metabolites (NOx) were measured as an index for NO production by HPLC combined with a Cd column, Griess reaction and a spectrophotometer in 403 healthy control subjects and 102 hospitalized patients with type 2 diabetes. Glucose infusion rate (GIR) was measured as a reverse index for insulin resistance by euglycemic glucose clamp study using an artificial pancreas in 20 of 102 diabetic patients. Urine NOx was lower in the patients with type 2 diabetes than in healthy control subjects (mean+/-SE: 3.18 +/-0.02 versus 3.25 +/-0.01 log[-micromol/gCr], p0.01). Urine NOx was correlated with body mass index (BMI) in 102 diabetic patients (r= -0.372, p0.001), but not related to either age, sex, fasting plasma glucose, HbA1c or blood pressure. Urine NOx was correlated with GIR independent of BMI in 20 diabetic patients (r=0.774, P0.0001). These findings suggest that NO production is closely related with insulin resistance in patients with type 2 diabetes. |
| تدمد: | 1348-4540 0918-8959 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8920072368c6bd93d37eb34e688473daTest https://doi.org/10.1507/endocrj.47.77Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....8920072368c6bd93d37eb34e688473da |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13484540 09188959 |
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