دورية أكاديمية
Amyloid imaging with carbon 11-labeled Pittsburgh compound B for traumatic brain injury.
| العنوان: | Amyloid imaging with carbon 11-labeled Pittsburgh compound B for traumatic brain injury. |
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| المؤلفون: | Hong, Young T, Veenith, Tonny, Dewar, Deborah, Outtrim, Joanne G, Mani, Vaithianadan, Williams, Claire, Pimlott, Sally, Hutchinson, Peter JA, Tavares, Adriana, Canales, Roberto, Mathis, Chester A, Klunk, William E, Aigbirhio, Franklin I, Coles, Jonathan P, Baron, Jean-Claude, Pickard, John D, Fryer, Tim D, Stewart, William, Menon, David K |
| بيانات النشر: | American Medical Association (AMA) //dx.doi.org/10.1001/jamaneurol.2013.4847 JAMA Neurol |
| سنة النشر: | 2014 |
| المجموعة: | Apollo - University of Cambridge Repository |
| مصطلحات موضوعية: | Adult, Aged, Amyloid beta-Peptides, Aniline Compounds, Brain, Brain Injuries, Carbon Radioisotopes, Cohort Studies, Female, Humans, Male, Middle Aged, Positron-Emission Tomography, Thiazoles, Time Factors, Tritium, Young Adult |
| الوصف: | OBJECTIVES: To image amyloid deposition in patients with traumatic brain injury (TBI) using carbon 11-labeled Pittsburgh Compound B ([11C]PiB) positron emission tomography (PET) and to validate these findings using tritium-labeled PiB ([3H]PiB) autoradiography and immunocytochemistry in autopsy-acquired tissue. DESIGN, SETTING, AND PARTICIPANTS: In vivo PET at tertiary neuroscience referral center and ex vivo immunocytochemistry of autopsy-acquired brain tissue from a neuropathology archive. [11C]PiB PET was used to image amyloid deposition in 11 controls (median [range] age, 35 [24-60] years) and in 15 patients (median [range] age, 33 [21-50] years) between 1 and 361 days after a TBI. [3H]PiB autoradiography and immunocytochemistry for β-amyloid (Aβ) and β-amyloid precursor protein in brain tissue were obtained from separate cohorts of 16 patients (median [range] age, 46 [21-70] years) who died between 3 hours and 56 days after a TBI and 7 controls (median [range] age, 61 [29-71] years) who died of other causes. MAIN OUTCOMES AND MEASURES: We quantified the [11C]PiB distribution volume ratio and standardized uptake value ratio in PET images. The distribution volume ratio and the standardized uptake value ratio were measured in cortical gray matter, white matter, and multiple cortical and white matter regions of interest, as well as in striatal and thalamic regions of interest. We examined [3H]PiB binding and Aβ and β-amyloid precursor protein immunocytochemistry in autopsy-acquired brain tissue. RESULTS: Compared with the controls, the patients with TBI showed significantly increased [11C]PiB distribution volume ratios in cortical gray matter and the striatum (corrected P < .05 for both), but not in the thalamus or white matter. Increases in [11C]PiB distribution volume ratios in patients with TBI were seen across most cortical subregions, were replicated using comparisons of standardized uptake value ratios, and could not be accounted for by methodological confounders. Autoradiography revealed [3H]PiB ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | Print; application/pdf; application/msword |
| اللغة: | English |
| العلاقة: | https://www.repository.cam.ac.uk/handle/1810/277171Test |
| DOI: | 10.17863/CAM.24461 |
| الإتاحة: | https://doi.org/10.17863/CAM.24461Test https://www.repository.cam.ac.uk/handle/1810/277171Test |
| رقم الانضمام: | edsbas.6164203 |
| قاعدة البيانات: | BASE |
| DOI: | 10.17863/CAM.24461 |
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