دورية أكاديمية
Association of Histologic Disease Activity With Progression of Nonalcoholic Fatty Liver Disease
| العنوان: | Association of Histologic Disease Activity With Progression of Nonalcoholic Fatty Liver Disease |
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| المؤلفون: | Kleiner, David E., Brunt, Elizabeth M., Wilson, Laura A., Behling, Cynthia, Guy, Cynthia, Contos, Melissa, Cummings, Oscar, Yeh, Matthew, Gill, Ryan, Chalasani, Naga, Neuschwander-Tetri, Brent A., Diehl, Anna Mae, Dasarathy, Srinivasan, Terrault, Norah, Kowdley, Kris, Loomba, Rohit, Belt, Patricia, Tonascia, James, Lavine, Joel E., Sanyal, Arun J., Nonalcoholic Steatohepatitis Clinical Research Network |
| المساهمون: | Medicine, School of Medicine |
| المصدر: | PMC |
| بيانات النشر: | JAMA Network |
| سنة النشر: | 2019 |
| المجموعة: | Indiana University - Purdue University Indianapolis: IUPUI Scholar Works |
| مصطلحات موضوعية: | Nonalcoholic Fatty Liver Disease, Hepatic fibrosis, Progression, Regression, Histologic evolution, Disease |
| الوصف: | Importance: The histologic evolution of the full spectrum of nonalcoholic fatty liver disease (NAFLD) and factors associated with progression or regression remain to be definitively established. Objective: To evaluate the histologic evolution of NAFLD and the factors associated with changes in disease severity over time. Design, Setting, and Participants: A prospective cohort substudy from the Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN) NAFLD Database study, a noninterventional registry, was performed at 8 university medical research centers. Masked assessment of liver histologic specimens was performed, using a prespecified protocol to score individual biopsies. Participants included 446 adults with NAFLD enrolled in the NASH CRN Database studies between October 27, 2004, and September 13, 2013, who underwent 2 liver biopsies 1 or more year apart. Data analysis was performed from October 2016 to October 2018. Main Outcomes and Measures: Progression and regression of fibrosis stage, using clinical, laboratory, and histologic findings, including the NAFLD activity score (NAS) (sum of scores for steatosis, lobular inflammation, and ballooning; range, 0-8, with 8 indicating more severe disease). Results: A total of 446 adults (mean [SD] age, 47 [11] years; 294 [65.9%] women) with NAFLD (NAFL, 86 [19.3%]), borderline NASH (84 [18.8%]), and definite NASH (276 [61.9%]) were studied. Over a mean (SD) interval of 4.9 (2.8) years between biopsies, NAFL resolved in 11 patients (12.8%) and progressed to steatohepatitis in 36 patients (41.9%). Steatohepatitis resolved in 24 (28.6%) of the patients with borderline NASH and 61 (22.1%) of those with definite NASH. Fibrosis progression or regression by at least 1 stage occurred in 132 (30%) and 151 [34%] participants, respectively. Metabolic syndrome (20 [95%] vs 108 [72%]; P = .03), baseline NAS (mean [SD], 5.0 [1.4] vs 4.3 [1.6]; P = .005), and smaller reduction in NAS (-0.2 [2] vs -0.9 [2]; P < .001) were associated with progression to advanced ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | JAMA Network Open; Kleiner, D. E., Brunt, E. M., Wilson, L. A., Behling, C., Guy, C., Contos, M., … Nonalcoholic Steatohepatitis Clinical Research Network (2019). Association of Histologic Disease Activity With Progression of Nonalcoholic Fatty Liver Disease. JAMA network open, 2(10), e1912565. doi:10.1001/jamanetworkopen.2019.12565; https://hdl.handle.net/1805/21413Test |
| الإتاحة: | https://doi.org/10.1001/jamanetworkopen.2019.12565Test https://hdl.handle.net/1805/21413Test |
| حقوق: | Attribution 4.0 International ; http://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: | edsbas.4F77EA28 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |