We observed that intravitreal injection of autologous blood in rabbits induced a disruption of blood-aqueous barriers, as demonstrated by slitlamp examination, fluorescein angiography of the iris and vascular carbon labeling. Following intravitreal injection of a high-molecular iron-dextrin complex (Ferrigen) a vascular damage developed in the anterior uvea, as demonstrated by carbon labeling of capillaries and venules in the iris and iridial processes. Indomethacin inhibited most of the inflammation in the anterior uvea, indicating that the reaction was, at least in part, mediated by Prostaglandins.