دورية أكاديمية
Wide-scope screening of pharmaceuticals, illicit drugs and their metabolites in the Amazon River
| العنوان: | Wide-scope screening of pharmaceuticals, illicit drugs and their metabolites in the Amazon River |
|---|---|
| المؤلفون: | Fabregat-Safont, David, Ibañez Martinez, Maria, Bijlsma, Lubertus, Hernandez, Felix, Waichman, Andrea, Oliveira, Rhaul, Rico, Andreu |
| بيانات النشر: | IWA Publishing Elsevier |
| سنة النشر: | 2021 |
| المجموعة: | Repositori Universitat Jaume I (Repositorio UJI) |
| مصطلحات موضوعية: | Pharmaceuticals, Freshwater ecosystems, Ion mobility, High-resolution mass spectrometry, Screening, Environmental monitoring |
| الوصف: | Only a limited number of households in the Amazon are served by sewage collection or treatment facili- ties, suggesting that there might be a significant emission of pharmaceuticals and other wastewater contaminants into freshwater ecosystems. In this work, we performed a wide-scope screening to assess the occurrence of pharmaceuticals, illicit drugs and their metabolites in freshwater ecosystems of the Brazilian Amazon. Our study included 40 samples taken along the Amazon River, in three of its major tributaries, and in small tributaries crossing four important urban areas (Manaus, Santarém, Macapá, Belém). More than 900 compounds were investigated making use of target and suspect screening approaches, based on liquid chromatography coupled to high-resolution mass spectrometry with ion mobility separation. Empirical collision-cross section (CCS) values were used to help and confirm identifications in target screening, while in the suspect screening approach CCS values were predicted using Artificial Neural Networks to increase the confidence of the tentative identification. In this way, 51 compounds and metabolites were identified. The highest prevalence was found in streams crossing the urban areas of Manaus, Macapáand Belém, with some samples containing up to 30 - 40 compounds, while samples taken in Santarém showed a lower number (8 - 11), and the samples taken in the main course of the Amazon River and its tributaries contained between 1 and 7 compounds. Most compounds identified in areas with significant urban impact belonged to the analgesics and antihypertensive categories, followed by stimulants and antibiotics. Compounds such as caffeine, cocaine and its metabolite benzoylecgonine, and cotinine (the metabolite of nicotine), were also detected in areas with relatively low anthropogenic impact and showed the highest total prevalence. This study supports the need to improve the sanitation system of urban areas in the Brazilian Amazon and the development of follow-up studies aimed at quantifying exposure ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 0043-1354 |
| العلاقة: | Proyecto de tesis doctorial de David Fabregat Safont: investigación sobre el uso de nuevas sustancias psicoactivas mediante técnicas de espectrometría de masas avanzadas; Investigación sobre el consumo de nuevas sustancias psicoactivas a través del análisis de los productos consumidos, in vivo e in vitro de NPS de especial interés; Estrategias analítcas para el control de contaminantes emergentes y evaluación de la eficacia de eliminación de procesos avanzados de oxidación en aguas residuales (annal_water_EC); Química analítica y salud pública, aportaciones de la espectrometría de masas de alta resolución; Estrategias analíticas avanzadas para el control y evaluación de contaminantes emergentes en aguas de riego; Water Research, 200, (2021); https://www.sciencedirect.com/science/article/pii/S0043135421004498Test#!; http://hdl.handle.net/10234/193509Test |
| DOI: | 10.1016/j.watres.2021.117251 |
| الإتاحة: | https://doi.org/10.1016/j.watres.2021.117251Test http://hdl.handle.net/10234/193509Test |
| حقوق: | http://creativecommons.org/licenses/by-sa/4.0Test/ ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.6841A57F |
| قاعدة البيانات: | BASE |
| تدمد: | 00431354 |
|---|---|
| DOI: | 10.1016/j.watres.2021.117251 |