التفاصيل البيبلوغرافية
| العنوان: |
Prevalence of classic and non-classic antiphospholipid antibodies in multiple sclerosis |
| المؤلفون: |
Shor D.B.-A., Weiss G.A., Barzilai O., Ram M., Anaya, Juan-Manuel, Shoenfeld Y., Sherer Y. |
| المصدر: |
instname:Universidad del Rosario |
| بيانات النشر: |
Israel Medical Association |
| سنة النشر: |
2015 |
| المجموعة: |
Universidad del Rosario, Bogotá: E-docUR |
| مصطلحات موضوعية: |
Beta2 glycoprotein 1, Cardiolipin antibody, Immunoglobulin g, Immunoglobulin m, Phosphatidylethanolamine, Phosphatidylserine, Phospholipid antibody, Prothrombin, Prothrombin complex, Adult, Antibody titer, Article, Controlled study, Disease duration, Female, Flow cytometry, Fluorescence analysis, Human, Immunoassay, Major clinical study, Male, Middle aged, Multiple sclerosis, Protein expression, Blood, Case control study, Cross-sectional study, Immunology, Prevalence, Case-control studies |
| الوصف: |
Background: The association between antiphospholipid antibodies (aPL) and multiple sclerosis (MS) has been suggested previously, but prior studies provided contradicting findings. Objectives: To characterize the expression profile of eight classic and non-classic aPL in patients diagnosed with MS. Methods: Using the BioPlex™ 2200 immunoassay, we measured the levels of serum immunoglobulin (Ig)M and IgG isotypes of three classic aPL and five non-classic aPL in 98 subjects with MS and 237 healthy controls. Results: Three non-classic aPL were significantly more prevalent among MS patients in comparison to the control group. These antibodies included IgM and IgG against phosphatidylserine- ?2GPI (PS-B2), IgG prothrombin complex (PT-PT) and IgM prothrombin (PT). The positive results according to Bonferroni correction are PS-B2 IgG and PT-PT IgG. The remaining aPL profiles did not differ significantly between the two groups. Conclusions: An association between certain non-classic aPL and MS has been established. The specific role of these autoantibodies in the pathogenesis of the condition remains uncertain. © 2015, Israel Medical Association. All rights reserved. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| تدمد: |
15651088 |
| العلاقة: |
https://repository.urosario.edu.co/handle/10336/22196Test |
| الإتاحة: |
https://repository.urosario.edu.co/handle/10336/22196Test |
| حقوق: |
info:eu-repo/semantics/openAccess |
| رقم الانضمام: |
edsbas.AA73C329 |
| قاعدة البيانات: |
BASE |
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