دورية أكاديمية
Shh, Bmp-2, Bmp-4 and Fgf-8 are associated with initiation and patterning of mouse tongue papillae
| العنوان: | Shh, Bmp-2, Bmp-4 and Fgf-8 are associated with initiation and patterning of mouse tongue papillae |
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| المؤلفون: | Thesleff, I, Oropeza, V, Jung, HS |
| بيانات النشر: | //www.elsevier.com/locate/modo Ireland |
| سنة النشر: | 1999 |
| المجموعة: | University of Hong Kong: HKU Scholars Hub |
| مصطلحات موضوعية: | Transforming Growth Factor Beta, Trans-Activators, Tongue - Embryology, Time Factors, Hematoxylin - Metabolism, In Situ Hybridization, Mice, Inbred Cba, Proteins - Analysis - Metabolism, Inbred Strains, Signal Transduction, Gene Expression Regulation, Developmental, Fibroblast Growth Factors - Analysis - Metabolism, Fibroblast Growth Factor 8, Eosine Yellowish-(Ys) - Metabolism, Bone Morphogenetic Proteins - Analysis - Metabolism, Bone Morphogenetic Protein 4, Bone Morphogenetic Protein 2, Animals, Hedgehog Proteins |
| الوصف: | Spacing patterns are of fundamental importance in various repeated structures which develop at regular intervals such as feathers, teeth and insect ommatidia. The mouse tongue develops a regular papilla pattern and provides a good model to study pattern formation. We examined the expression patterns of the signalling molecules, sonic hedgehog (Shh), bone morphogenetic proteins -2 and -4 (Bmp-2 and Bmp-4), and fibroblast growth factor-8 (Fgf-8) in mouse embryos between E 10.5 and 15. We show that all four genes are expressed uniformly in the tongue epithelium between E 10.5 and 11. At E 13, before morphologically detectable gustatory papillae initiation, Shh, Bmp-2 and Bmp-4 expression segregates into discrete spots, whereas, Fgf-8 is downregulated. At E 14, small eminences in the anterior part of the tongue are the first morphological indications of fungiform papillae, and they express Shh and Bmp-2, whereas, Bmp-4 is almost absent in the tongue. We conclude that these conserved signalling molecules are associated with the initiation and early morphogenesis of the tongue papillae. ; link_to_subscribed_fulltext |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0925-4773 10330496 |
| العلاقة: | Mechanisms of Development; http://www.scopus.com/mlt/select.url?eid=2-s2.0-0032962770&selection=ref&src=s&origin=recordpageTest; Mechanisms Of Development, 1999, v. 81 n. 1-2, p. 179-182; 182; WOS:000079754600016; 1-2; eid_2-s2.0-0032962770; 179; http://hdl.handle.net/10722/169532Test; 81 |
| DOI: | 10.1016/S0925-4773(98)00234-2 |
| الإتاحة: | https://doi.org/10.1016/S0925-4773Test(98)00234-2 http://hdl.handle.net/10722/169532Test |
| رقم الانضمام: | edsbas.741E54E0 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 09254773 10330496 |
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| DOI: | 10.1016/S0925-4773(98)00234-2 |