التفاصيل البيبلوغرافية
| العنوان: |
Changes in the electrical activity of prefrontal neurons following methamphetamine-induced conditioned place preference in the rat. |
| المؤلفون: |
Taslimi, Zahra, Sarihi, Abdolrahman, Karimi, Sara, Haghparast, Abbas |
| المصدر: |
Physiology & Pharmacology; Sep2022, Vol. 26 Issue 3, p288-298, 11p |
| مصطلحات موضوعية: |
REWARD (Psychology), NEURONS, RATS, METHAMPHETAMINE |
| مستخلص: |
Introduction: Methamphetamine (METH) addiction is an epidemic-growing problem globally. Studies confirmed a solid linkage between the prefrontal cortex (PFC) and drugseeking. The present study aimed to investigate PFC neural activity changes after injection of METH following METH-induced conditioned place preference (CPP) in the rats. Methods: After the development of CPP (0.5mg/kg METH for three days, SC), in vivo single-unit recordings were carried out the day after the post-test (post-conditioning day). On recording day, after stabilization and baseline recording (a 10-min period), the injection of METH (0.5mg/kg, SC) was performed and then, PFC neural activity was recorded for a 30-min period. Results: The results revealed that the injection of METH on the post-conditioning test significantly increases PFC neurons’ firing rate in animals that received METH during the CPP paradigm. Conclusion: It seems that maybe, PFC neurons appear to be implicated in the associated METH reward pathway and repeated exposure to METH affected the sensitivity of neurons in this area. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
