دورية أكاديمية
أعرض في EDS

Cognitive Trajectories in Preclinical and Prodromal Alzheimer's Disease Related to Amyloid Status and Brain Atrophy: A Bayesian Approach.

التفاصيل البيبلوغرافية
العنوان: Cognitive Trajectories in Preclinical and Prodromal Alzheimer's Disease Related to Amyloid Status and Brain Atrophy: A Bayesian Approach.
المؤلفون: Teipel, Stefan J, Dyrba, Martin, Levin, Fedor, Altenstein, Slawek, Berger, Moritz, Beyle, Aline, Brosseron, Frederic, Buerger, Katharina, Burow, Lena, Dobisch, Laura, Ewers, Michael, Fliessbach, Klaus, Frommann, Ingo, Glanz, Wenzel, Goerss, Doreen, Gref, Daria, Hansen, Niels, HENEKA, Michael, Incesoy, Enise I, Janowitz, Daniel, Keles, Deniz, Kilimann, Ingo, Laske, Christoph, Lohse, Andrea, Munk, Matthias H, Perneczky, Robert, Peters, Oliver, Preis, Lukas, Priller, Josef, Rostamzadeh, Ayda, Roy, Nina, Schmid, Matthias, Schneider, Anja, Spottke, Annika, Spruth, Eike Jakob, Wiltfang, Jens, Düzel, Emrah, Jessen, Frank, Kleineidam, Luca, Wagner, Michael, DELCODE study group and the Alzheimer’s Disease Neuroimaging Initiative
المصدر: Journal of Alzheimer's disease reports, 7 (1), 1055 - 1076 (2023)
بيانات النشر: IOS Press BV
سنة النشر: 2023
المجموعة: University of Luxembourg: ORBilu - Open Repository and Bibliography
مصطلحات موضوعية: Alzheimer’s disease, executive function, longitudinal, memory, mild cognitive impairment, non-linear, practice effects, subjective cognitive decline, Neuroscience (all), Clinical Psychology, Geriatrics and Gerontology, Psychiatry and Mental Health, General Neuroscience, Human health sciences, Neurology, Sciences de la santé humaine, Neurologie
الوصف: peer reviewed ; [en] BACKGROUND: Cognitive decline is a key outcome of clinical studies in Alzheimer's disease (AD). OBJECTIVE: To determine effects of global amyloid load as well as hippocampus and basal forebrain volumes on longitudinal rates and practice effects from repeated testing of domain specific cognitive change in the AD spectrum, considering non-linear effects and heterogeneity across cohorts. METHODS: We included 1,514 cases from three cohorts, ADNI, AIBL, and DELCODE, spanning the range from cognitively normal people to people with subjective cognitive decline and mild cognitive impairment (MCI). We used generalized Bayesian mixed effects analysis of linear and polynomial models of amyloid and volume effects in time. Robustness of effects across cohorts was determined using Bayesian random effects meta-analysis. RESULTS: We found a consistent effect of amyloid and hippocampus volume, but not of basal forebrain volume, on rates of memory change across the three cohorts in the meta-analysis. Effects for amyloid and volumetric markers on executive function were more heterogeneous. We found practice effects in memory and executive performance in amyloid negative cognitively normal controls and MCI cases, but only to a smaller degree in amyloid positive controls and not at all in amyloid positive MCI cases. CONCLUSIONS: We found heterogeneity between cohorts, particularly in effects on executive functions. Initial increases in cognitive performance in amyloid negative, but not in amyloid positive MCI cases and controls may reflect practice effects from repeated testing that are lost with higher levels of cerebral amyloid.
نوع الوثيقة: article in journal/newspaper
اللغة: English
تدمد: 2542-4823
العلاقة: https://content.iospress.com/download?id=10.3233/ADR-230027Test; urn:issn:2542-4823; https://orbilu.uni.lu/handle/10993/57592Test; info:hdl:10993/57592; https://orbilu.uni.lu/bitstream/10993/57592/1/Teipel%20et%20al%202023.pdfTest; scopus-id:2-s2.0-85173994209; info:pmid:37849637; wos:001079384000001
DOI: 10.3233/ADR-230027
الإتاحة: https://doi.org/10.3233/ADR-230027Test
https://orbilu.uni.lu/handle/10993/57592Test
https://orbilu.uni.lu/bitstream/10993/57592/1/Teipel%20et%20al%202023.pdfTest
حقوق: open access ; http://purl.org/coar/access_right/c_abf2Test ; info:eu-repo/semantics/openAccess
رقم الانضمام: edsbas.3D73C912
قاعدة البيانات: BASE
الوصف
تدمد:25424823
DOI:10.3233/ADR-230027