التفاصيل البيبلوغرافية
| العنوان: |
Inflammation-Related microRNAs-146a and -155 Are Upregulated in Mild Cognitive Impairment Subjects Among Older Age Population in Montenegro. |
| المؤلفون: |
Rovčanin Dragović, Isidora, Popović, Nataša, Ždralević, Maša, Radulović, Ljiljana, Vuković, Tijana, Marzano, Flaviana, Tullo, Apollonia, Radunović, Miodrag |
| المصدر: |
Journal of Alzheimer's Disease; 2022, Vol. 90 Issue 2, p625-638, 14p |
| مصطلحات موضوعية: |
MILD cognitive impairment, POPULATION aging, GENE expression, ALZHEIMER'S disease, NEUROPSYCHOLOGICAL tests, APOLIPOPROTEIN E4, RNA metabolism, ALZHEIMER'S disease diagnosis, INFLAMMATION |
| مصطلحات جغرافية: |
MONTENEGRO, EASTERN Europe |
| مستخلص: |
Background: Pathological and clinical features of Alzheimer's disease (AD) are in temporal discrepancy and currently accepted clinical tests provide the diagnosis decades after the initial pathophysiological events. In order to enable a more timely detection of AD, research efforts are directed to identification of biomarkers of the early symptomatic stage. Neuroinflammatory signaling pathways and inflammation-related microRNAs (miRNAs) could possibly have a crucial role in AD, making them promising potential biomarkers.Objective: We examined the expression of circulatory miRNAs with a documented role in AD pathophysiology: miR-29a/b, miR-101, miR-125b, miR-146a, and miR-155 in the plasma of AD patients (AD, n = 12), people with mild cognitive impairment (MCI, n = 9), and normocognitive group (CTRL, n = 18). We hypothesized that these miRNA expression levels could correlate with the level of participants' cognitive decline.Methods: The study participants completed the standardized interview, neurological examination, neuropsychological assessment, and biochemical analyses. miRNA expression levels were assessed by RT-PCR.Results: Neurological and laboratory findings could not account for MCI, but miR-146a and -155 were upregulated in the MCI group compared to the control. miR-146a, known to mediate early neuroinflammatory AD events, was also upregulated in the MCI compared to AD group. ROC curve analysis for miRNA-146a showed 77.8% sensitivity and 94.4% specificity and 66.7% sensitivity and 88.9% specificity for miR-155.Conclusion: Determination of circulatory inflamma-miRs-146a and -155 expression, together with neuropsychological screening, could become a non-invasive tool for detecting individuals with an increased risk for AD, but research on a larger cohort is warranted. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
