Subtle Differences in Cognition in 70-Year-Olds with Elevated Cerebrospinal Fluid Neurofilament Light and Neurogranin: A H70 Cross-Sectional Study
| العنوان: | Subtle Differences in Cognition in 70-Year-Olds with Elevated Cerebrospinal Fluid Neurofilament Light and Neurogranin: A H70 Cross-Sectional Study |
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| المؤلفون: | Maya Arvidsson, Rådestig, Johan, Skoog, Henrik, Zetterberg, Tobias, Skillbäck, Anna, Zettergren, Therese Rydberg, Sterner, Madeleine Mellqvist, Fässberg, Simona, Sacuiu, Margda, Waern, Hanna, Wetterberg, Kaj, Blennow, Ingmar, Skoog, Silke, Kern |
| المصدر: | Journal of Alzheimer's Disease. 91:291-303 |
| بيانات النشر: | IOS Press, 2023. |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Psychiatry and Mental health, Clinical Psychology, General Neuroscience, General Medicine, Geriatrics and Gerontology |
| الوصف: | Background: Most research on cerebrospinal fluid (CSF) neurofilament light protein (NfL) as a marker for neurodegeneration and neurogranin (Ng) for synaptic dysfunction has largely focused on clinical cohorts rather than population-based samples. Objective: We hypothesized that increased CSF levels of NfL and Ng are associated with subtle cognitive deficits in cognitively unimpaired (CU) older adults. Methods: The sample was derived from the Gothenburg H70 Birth Cohort Studies and comprised 258 CU 70-year-olds, with a Clinical Dementia Rating score of zero. All participants underwent extensive cognitive testing. CSF levels of NfL and Ng, as well as amyloid β1 - 42, total tau, and phosphorylated tau, were measured. Results: Participants with high CSF NfL performed worse in one memory-based test (Immediate recall, p = 0.013) and a language test (FAS, p = 0.016). Individuals with high CSF Ng performed worse on the memory-based test Supra Span (p = 0.035). When stratified according to CSF tau and Aβ42 concentrations, participants with high NfL and increased tau performed worse on a memory test than participants normal tau concentrations (Delayed recall, p = 0.003). In participants with high NfL, those with pathologic Aβ42 concentrations performed worse on the Delayed recall memory (p = 0.044). In the high Ng group, participants with pathological Aβ42 concentrations had lower MMSE scores (p = 0.027). However, in regression analysis we found no linear correlations between CSF NfL or CSF Ng in relation to cognitive tests when controlled for important co-variates. Conclusion: Markers of neurodegeneration and synaptic pathology might be associated with subtle signs of cognitive decline in a population-based sample of 70-year-olds. |
| تدمد: | 1875-8908 1387-2877 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb3eba3dc0d8bb04bd7e315d9f33d471Test https://doi.org/10.3233/jad-220452Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....bb3eba3dc0d8bb04bd7e315d9f33d471 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18758908 13872877 |
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