Gut microbiota and Crohn’s disease
| العنوان: | Gut microbiota and Crohn’s disease |
|---|---|
| المؤلفون: | Anna Testa, Antonio Rispo, Fabiana Castiglione, Giovanna Trinchese, Nicola Imperatore, Maria Pina Mollica, Gina Cavaliere, Olga Maria Nardone |
| المساهمون: | Testa, A, Rispo, A, Imperatore, N, Nardone, Om, Trinchese, G, Cavaliere, G, Castiglione, F, Mollica, Mp |
| المصدر: | Mediterranean Journal of Nutrition and Metabolism. 11:65-72 |
| بيانات النشر: | IOS Press, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, Crohn's disease, Nutrition and Dietetics, biology, Endocrinology, Diabetes and Metabolism, Gut microbiota, Gut flora, biology.organism_classification, medicine.disease, digestive system, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Crohn's disease, Gut microbiota, Immunology, medicine, 030211 gastroenterology & hepatology, Food Science |
| الوصف: | INTRODUCTION: Crohn’s disease (CD) is characterized by a chronic inflammation of the gastrointestinal tract causing abdominal pain, diarrhea, weight loss and systemic symptoms. Although the etiology of this disease is unknown, current knowledge suggests a multifactorial genesis involving genetic, environmental and immunological factors. EVIDENCE ACQUISITION: We focused our attention on critical analysis of the recent literature on the role of gut microbiota in inflammatory bowel disease (IBD), by evaluating the differences of composition, functions and role of intestinal flora. In particular, we focused on evidences about the interaction between gut microbiota and pathogenesis of IBD. In this setting, we conducted a PUBMED search for guidelines, systematic reviews (SR) and primary studies. EVIDENCE SYNTHESIS: Some data suggest that, in a significant percentage of patients, the microbiota plays an important role in the genesis and maintenance of CD. Probiotic supplementation and antibiotic treatment appear to be a valid therapeutic approach, although the clinical data remain controversial. CONCLUSIONS: Despite the exciting and growing research on the role of gut microbiota in IBD, our knowledge remains fairly limited. Further studies are needed to measure the diversity, function and resistance to antibiotics of the intestinal microbiota in CD. |
| تدمد: | 1973-7998 1973-798X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39a36400ff0a9dbb838e27a6f281f2d1Test https://doi.org/10.3233/mnm-17182Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....39a36400ff0a9dbb838e27a6f281f2d1 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19737998 1973798X |
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