PAN-811 Inhibits Oxidative Stress-Induced Cell Death of Human Alzheimer's Disease-Derived and Age-Matched Olfactory Neuroepithelial Cells Via Suppression of Intracellular Reactive Oxygen Species
| العنوان: | PAN-811 Inhibits Oxidative Stress-Induced Cell Death of Human Alzheimer's Disease-Derived and Age-Matched Olfactory Neuroepithelial Cells Via Suppression of Intracellular Reactive Oxygen Species |
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| المؤلفون: | Hossein A. Ghanbari, Michael S. Lebowitz, Weiying Pan, Zhi-Gang Jiang, Valery Nelson, Chanteé M. Dancik |
| المصدر: | Journal of Alzheimer's Disease. 17:611-619 |
| بيانات النشر: | IOS Press, 2009. |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | Thiosemicarbazones, Aging, Programmed cell death, Pyridines, Neuroepithelial Cells, Oxidative phosphorylation, Biology, medicine.disease_cause, Basal (phylogenetics), Alzheimer Disease, medicine, Humans, Senile plaques, Cell damage, Aged, Analysis of Variance, Cell Death, Dose-Response Relationship, Drug, L-Lactate Dehydrogenase, General Neuroscience, Neurotoxicity, Extracellular Fluid, Hydrogen Peroxide, Olfactory Pathways, General Medicine, Oxidants, medicine.disease, Cell biology, Neuroepithelial cell, Oxidative Stress, Psychiatry and Mental health, Clinical Psychology, Neuroprotective Agents, Case-Control Studies, Geriatrics and Gerontology, Reactive Oxygen Species, Oxidative stress |
| الوصف: | Oxidative stress plays a significant role in neurotoxicity associated with a variety of neurodegenerative diseases including Alzheimer's disease (AD). Increased oxidative stress has been shown to be a prominent and early feature of vulnerable neurons in AD. Olfactory neuroepithelial cells are affected at an early stage. Exposure to oxidative stress induces the accumulation of intracellular reactive oxygen species (ROS), which in turn causes cell damage in the form of protein, lipid, and DNA oxidations. Elevated ROS levels are also associated with increased deposition of amyloid-beta and formation of senile plaques, a hallmark of the AD brain. If enhanced ROS exceeds the basal level of cellular protective mechanisms, oxidative damage and cell death will result. Therefore, substances that can reduce oxidative stress are sought as potential drug candidates for treatment or preventative therapy of neurodegenerative diseases such as AD. PAN-811, also known as 3-aminopyridine-2-carboxaldehyde thiosemicarbazone or Triapine, is a small lipophilic compound that is currently being investigated in several Phase II clinical trials for cancer therapy due to its inhibition of ribonucleotide reductase activity. Here we show PAN-811 to be effective in preventing or reducing ROS accumulation and the resulting oxidative damages in both AD-derived and age-matched olfactory neuroepithelial cells. |
| تدمد: | 1875-8908 1387-2877 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::405d3469f016c3ac8f990ddb02f34df7Test https://doi.org/10.3233/jad-2009-1078Test |
| رقم الانضمام: | edsair.doi.dedup.....405d3469f016c3ac8f990ddb02f34df7 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18758908 13872877 |
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