Epidemiological evaluation of spatiotemporal and genotypic clustering of Mycobacterium tuberculosis in Ontario, Canada
| العنوان: | Epidemiological evaluation of spatiotemporal and genotypic clustering of Mycobacterium tuberculosis in Ontario, Canada |
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| المؤلفون: | D N Fisman, Ashleigh R. Tuite, David C. Alexander, Frances B. Jamieson, B Lee, K Lam, M S Whelan, J Ma, Jennifer L. Guthrie |
| المصدر: | The International Journal of Tuberculosis and Lung Disease. 17:1322-1327 |
| بيانات النشر: | International Union Against Tuberculosis and Lung Disease, 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Pulmonary and Respiratory Medicine, medicine.medical_specialty, Tuberculosis, biology, business.industry, Odds ratio, medicine.disease, biology.organism_classification, Logistic regression, Confidence interval, law.invention, Mycobacterium tuberculosis, Infectious Diseases, Transmission (mechanics), law, Epidemiology, medicine, Risk factor, business, Demography |
| الوصف: | Background In Canada, tuberculosis (TB) rates are at a historic low, with the remaining risk concentrated in a few vulnerable population subgroups. Objectives To describe the epidemiology of TB in the Canadian province of Ontario and to characterise risk factors associated with transmission events, identified using genetic typing techniques. Design Retrospective analysis of 2186 culture-positive TB cases between August 2007 and December 2011. Temporal trends and risk of spatiotemporal and genotypic clustering were evaluated using Poisson and logistic regression models. Results Being in a spatiotemporal cluster was associated with Aboriginal status (odds ratio [OR] 3.63, 95% confidence interval [CI] 1.23-10.71). Cases in genotypic clusters were more likely to report homelessness as a risk factor (adjusted OR [aOR] 2.92, 95%CI 1.74-4.90) or be male (aOR 1.35, 95%CI 1.09-1.68), and were less likely to be aged ≥ 65 years (aOR 0.63, 95%CI 0.49-0.82), foreign-born (aOR 0.32, 95%CI 0.24-0.43) or Aboriginal (aOR 0.40, 95%CI 0.16-0.99). The Beijing lineage had an annual rate of increase of almost 10% (P = 0.047), and was associated with genotypic clustering (aOR 2.84, 95%CI 2.19-3.67). Conclusion Genotypic data suggest that disease clusters are smaller, but far more common, than would be estimated using spatiotemporal clustering. |
| تدمد: | 1815-7920 1027-3719 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::bff88e85d1d024478af3cea8cc97a090Test https://doi.org/10.5588/ijtld.13.0145Test |
| رقم الانضمام: | edsair.doi...........bff88e85d1d024478af3cea8cc97a090 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18157920 10273719 |
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