دورية أكاديمية
Fine-scale mapping of 8q24 locus identifies multiple independent risk variants for breast cancer.
العنوان: | Fine-scale mapping of 8q24 locus identifies multiple independent risk variants for breast cancer. |
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المؤلفون: | Shi, J, Zhang, Y, Zheng, W, Michailidou, K, Ghoussaini, M, Bolla, MK, Wang, Q, Dennis, J, Lush, M, Milne, RL, Shu, X-O, Beesley, J, Kar, S, Andrulis, IL, Anton-Culver, H, Arndt, V, Beckmann, MW, Zhao, Z, Guo, X, Benitez, J, Beeghly-Fadiel, A, Blot, W, Bogdanova, NV, Bojesen, SE, Brauch, H, Brenner, H, Brinton, L, Broeks, A, Brüning, T, Burwinkel, B, Cai, H, Canisius, S, Chang-Claude, J, Choi, J-Y, Couch, FJ, Cox, A, Cross, SS, Czene, K, Darabi, H, Devilee, P, Droit, A, Dork, T, Fasching, PA, Fletcher, O, Flyger, H, Fostira, F, Gaborieau, V, García-Closas, M, Giles, GG, Grip, M, Guenel, P, Haiman, CA, Hamann, U, Hartman, M, Miao, H, Hollestelle, A, Hopper, JL, Hsiung, C-N, kConFab Investigators, Ito, H, Jakubowska, A, Johnson, N, Torres, D, Kabisch, M, Kang, D, Khan, S, Knight, JA, Kosma, V-M, Lambrechts, D, Li, J, Lindblom, A, Lophatananon, A, Lubinski, J, Mannermaa, A, Manoukian, S, Le Marchand, L, Margolin, S, Marme, F, Matsuo, K, McLean, C, Meindl, A, Muir, K, Neuhausen, SL, Nevanlinna, H, Nord, S, Børresen-Dale, A-L, Olson, JE, Orr, N, van den Ouweland, AMW, Peterlongo, P, Choudary Putti, T, Rudolph, A, Sangrajrang, S, Sawyer, EJ, Schmidt, MK, Schmutzler, RK, Shen, C-Y, Hou, M-F, Shrubsole, MJ, Southey, MC, Swerdlow, A, Hwang Teo, S, Thienpont, B, Toland, AE, Tollenaar, RAEM, Tomlinson, I, Truong, T, Tseng, C-C, Wen, W, Winqvist, R, Wu, AH, Har Yip, C, Zamora, PM, Zheng, Y, Floris, G, Cheng, C-Y, Hooning, MJ, Martens, JWM, Seynaeve, C, Kristensen, VN, Hall, P, Pharoah, PDP, Simard, J, Chenevix-Trench, G, Dunning, AM, Antoniou, AC, Easton, DF, Cai, Q, Long, J |
بيانات النشر: | Wiley-Blackwell //dx.doi.org/10.1002/ijc.30150 International Journal of Cancer |
سنة النشر: | 2016 |
المجموعة: | Apollo - University of Cambridge Repository |
مصطلحات موضوعية: | 8q24, breast cancer, fine-mapping, genetic susceptibility, single nucleotide polymorphism |
الوصف: | Previous genome-wide association studies among women of European ancestry identified two independent breast cancer susceptibility loci represented by single nucleotide polymorphisms (SNPs) rs13281615 and rs11780156 at 8q24. A fine-mapping study across 2.06 Mb (chr8:127,561,724-129,624,067, hg19) in 55,540 breast cancer cases and 51,168 controls within the Breast Cancer Association Consortium was conducted. Three additional independent association signals in women of European ancestry, represented by rs35961416 (OR = 0.95, 95% CI = 0.93-0.97, conditional p = 5.8 × 10(-6) ), rs7815245 (OR = 0.94, 95% CI = 0.91-0.96, conditional p = 1.1 × 10(-6) ) and rs2033101 (OR = 1.05, 95% CI = 1.02-1.07, conditional p = 1.1 × 10(-4) ) were found. Integrative analysis using functional genomic data from the Roadmap Epigenomics, the Encyclopedia of DNA Elements project, the Cancer Genome Atlas and other public resources implied that SNPs rs7815245 in Signal 3, and rs1121948 in Signal 5 (in linkage disequilibrium with rs11780156, r(2) = 0.77), were putatively functional variants for two of the five independent association signals. The results highlighted multiple 8q24 variants associated with breast cancer susceptibility in women of European ancestry. ; CRUK, NIH, fp7 Numerous funders. Details can be found within the financial support section of the manuscript. |
نوع الوثيقة: | article in journal/newspaper |
وصف الملف: | application/pdf |
اللغة: | English |
العلاقة: | https://www.repository.cam.ac.uk/handle/1810/254522Test |
الإتاحة: | https://www.repository.cam.ac.uk/handle/1810/254522Test |
رقم الانضمام: | edsbas.8D14B3AE |
قاعدة البيانات: | BASE |
الوصف غير متاح. |