Low Incidence of Hemorrhagic Infarction Following Coronary Reperfusion with Nasaruplase in a Canine Model of Acute Myocardial Infarction. Comparison with Recombinant t-PA
| العنوان: | Low Incidence of Hemorrhagic Infarction Following Coronary Reperfusion with Nasaruplase in a Canine Model of Acute Myocardial Infarction. Comparison with Recombinant t-PA |
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| المؤلفون: | Masahiro Watanabe, Kazutaka Hayashi, Takeshi Uchida, Hideaki Kido |
| المصدر: | Japanese Heart Journal. 36:61-79 |
| بيانات النشر: | International Heart Journal (Japanese Heart Journal), 1995. |
| سنة النشر: | 1995 |
| مصطلحات موضوعية: | medicine.medical_specialty, biology, business.industry, medicine.medical_treatment, Fissipedia, Thrombolysis, medicine.disease, biology.organism_classification, Fibrinogen, medicine.anatomical_structure, Internal medicine, Fibrinolysis, medicine, Cardiology, Myocardial infarction, Thrombus, Cardiology and Cardiovascular Medicine, business, Plasminogen activator, medicine.drug, Artery |
| الوصف: | An examination was made of the coronary thrombolytic effects of nasaruplase in a canine model of acute myocardial infarction. The model was produced by selective injection of an artificial thrombus into the coronary artery stenosed by laser ablation. Intravenous nasaruplase (8U/kg/min) showed an equivalent thrombolytic effect to a recombinant tissue-type plasminogen activator (rt-PA, 10, 000IU/kg/min) as assessed by reperfusion rate (78.6 versus 79.2%) and reperfusion time (37.4±5.2 versus 37.0±2.5min). Nasaruplase decreased the plasma α2-plasmin inhibitor (α2-PI) level by 28% immediately after reperfusion, but hardly altered fibrinogen or plasmin-α2-plasmin inhibitor complex (PIC) levels. By contrast, rt-PA significantly decreased plasma α2-PI and fibrinogen levels, by 84% and 92% respectively, and, increased PIC level more than 70-fold. Hemorrhagic infarction occurred in 2 of 14 animals in the nasaruplase group and in 9 of 19 animals in the rt-PA group. In these animals, significant correlations were found between the ratio of the hemorrhagic infarction area to total infarct area and the plasma α2-PI (r=-0.740, p |
| تدمد: | 1348-673X 0021-4868 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::e1e254f63949a4638024f2357143aec5Test https://doi.org/10.1536/ihj.36.61Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi...........e1e254f63949a4638024f2357143aec5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1348673X 00214868 |
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