دورية أكاديمية
Recurrent implantation failure: reality or a statistical mirage? Consensus statement from the July 1, 2022 Lugano Workshop on recurrent implantation failure. ; Fallo de implantación recurrente: ¿realidad o espejismo estadístico? Declaración de consenso del taller de Lugano del 1 de julio de 2022 sobre el fallo de implantación recurrente.
| العنوان: | Recurrent implantation failure: reality or a statistical mirage? Consensus statement from the July 1, 2022 Lugano Workshop on recurrent implantation failure. ; Fallo de implantación recurrente: ¿realidad o espejismo estadístico? Declaración de consenso del taller de Lugano del 1 de julio de 2022 sobre el fallo de implantación recurrente. |
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| المساهمون: | Ata, Mustafa Barış (ORCID 0000-0003-1106-3747 & YÖK ID 182910), Pirtea, Paul, Cedars, Marcelle I., Devine, Kate, Franasiak, Jason, Racowsky, Catherine, Toner, Jim, Scott, Richard T., de Ziegler, Dominique, Barnhart, Kurt T., School of Medicine |
| المصدر: | Fertility and Sterility |
| بيانات النشر: | Elsevier International |
| سنة النشر: | 2023 |
| المجموعة: | Koç University Suna Kıraç Library’ Digital Collections |
| مصطلحات موضوعية: | Obstetrics and gynecology, Reproductive biology, Endometrial receptivity, IVF failure, FET, Frozen embryo transfer, PGT-A, Recurrent implantation failure (RIF) |
| الوصف: | Importance: to date, recurrent implantation failure (RIF) has no clear definition and no clearly identified impaired function. Hence, the term RIF is currently used somewhat haphazardly, on the basis of clinicians’ judgment. Objective: international experts in reproductive medicine met on July 1, 2022, in Lugano, Switzerland, to review the different facets of RIF and define the diagnosis and its appropriate management. Evidence Review: a systematic review without meta-analysis of studies published in English from January 2015 to May 2022. Findings: data indicated that RIF has been largely overevaluated, overdiagnosed, and overtreated without sufficient critical assessment of its true nature. Our analyses show that true RIF is extremely uncommon—occurring in <5% of couples with infertility—and that reassurance and continued conventional therapies are warranted in most cases of assisted reproductive technology (ART) failure. Although the true biologic determinants of RIF may exist in a small subset of people with infertility, they elude the currently available tools for assessment. Without identification of the true underlying etiology(ies), it is reasonable not to assign this diagnosis to a patient until she has failed at least 3 euploid blastocyst transfers (or the equivalent number of unscreened embryo transfers, adjusted to the patient’s age and corresponding euploidy rate). In addition, other factors should be ruled out that may contribute to her reduced odds of sustained implantation. In such cases, implantation failure should not be the only issue considered in case of ART failure because this may result from multiple other factors that are not necessarily repetitive or persistent. In reality, RIF impacting the probability of further ART success is a very rare occurrence. Conclusion: true RIF is extremely uncommon, occurring in <5% of couples with infertility. Reassurance and continued conventional therapies are warranted in most cases. It would seem reasonable not to assign this diagnosis to a ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | |
| اللغة: | English |
| تدمد: | 0015-0282 1556-5653 |
| العلاقة: | Publisher version; Koç University Institutional Repository; IR04323; Pirtea, Paul, et al. “Recurrent implantation failure: Reality or a statistical mirage?” Fertility and Sterility, vol. 120, no. 1, July 2023, pp. 45–59, https://doi.org/10.1016/j.fertnstert.2023.02.014Test.; https://dx.doi.org/10.1016/j.fertnstert.2023.02.014Test; WoS; Scopus; Pubmed; NA; http://libdigitalcollections.ku.edu.tr/cdm/ref/collection/IR/id/11206Test |
| DOI: | 10.1016/j.fertnstert.2023.02.014 |
| الإتاحة: | https://doi.org/10.1016/j.fertnstert.2023.02.014Test http://libdigitalcollections.ku.edu.tr/cdm/ref/collection/IR/id/11206Test |
| رقم الانضمام: | edsbas.2BD62825 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 00150282 15565653 |
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| DOI: | 10.1016/j.fertnstert.2023.02.014 |