Potential effect of Zika virus infection on human male fertility?
| العنوان: | Potential effect of Zika virus infection on human male fertility? |
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| المؤلفون: | Erika R. Manuli, Cynthia Liliane Motta do Canto, Ester Cerdeira Sabino, Carolina Abreu, Philippe Mayaud, Maria Cassia Mendes-Correa, Vivian Iida Avelino-Silva, Aluísio Augusto Cotrim Segurado, Walter Manso Figueiredo, Conrado Alvarenga, Tania Regina Tozetto-Mendoza |
| المصدر: | Revista do Instituto de Medicina Tropical de São Paulo, Volume: 60, Article number: e64, Published: 25 OCT 2018 Revista do Instituto de Medicina Tropical de São Paulo, Vol 60, Iss 0 (2018) Revista do Instituto de Medicina Tropical de São Paulo Revista do Instituto de Medicina Tropical de São Paulo; Vol. 60 (2018); e64 Revista do Instituto de Medicina Tropical de São Paulo; v. 60 (2018); e64 Instituto de Medicina Tropical (IMT) instacron:IMT |
| بيانات النشر: | Instituto de Medicina Tropical, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, Sexual transmission, lcsh:Arctic medicine. Tropical medicine, Shedding. Semen, lcsh:RC955-962, media_common.quotation_subject, Semen, Fertility, Case Report, Spermogram, Biology, Zika virus, 03 medical and health sciences, 0302 clinical medicine, 030212 general & internal medicine, media_common, Shedding, Potential effect, biology.organism_classification, 3. Good health, 030104 developmental biology, Male fertility, Brazil, Demography |
| الوصف: | Background: Zika virus (ZIKV) sexual transmission and prolonged viral shedding in semen have been previously reported, suggesting a strong viral affinity for genital tissues. A transient impact of ZIKV on male fertility was shown in animal and human studies. Methods: Adult male patients with confirmed ZIKV infection diagnosed in the city of Araraquara, Brazil during the epidemic season of 2016 were invited one year after the acute infection to respond to a questionnaire of genital symptoms and to provide a semen sample for molecular ZIKV testing and spermogram analysis, as well as a serum sample for hormonal testing. Results: 101 of 187 tested patients had positive ZIKV RT-PCR in plasma and/or urine samples (54%, 72 women and 29 men). Of 15 adult male participants for whom telephone contact was successful, 14 responded to the questionnaire of genital symptoms and six consented to provide a semen sample at a median of 12 months after the acute infection. We report abnormal spermogram results from patients one year after confirmed ZIKV infection. Conclusions: Our findings suggest a possible long-term detrimental effect of ZIKV infection on human male fertility that has to be further explored in well-characterized samples from cohort studies conducted in ZIKV-endemic areas. |
| وصف الملف: | text/html; application/pdf; application/xml |
| اللغة: | English |
| تدمد: | 0036-4665 1678-9946 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30d01264c31c47a0f6bb8b653a26907dTest http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652018005000507&lng=en&tlng=enTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....30d01264c31c47a0f6bb8b653a26907d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 00364665 16789946 |
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