Nano‐gold micelles loaded Dox and Elacridar for reversing drug resistance of breast cancer
| العنوان: | Nano‐gold micelles loaded Dox and Elacridar for reversing drug resistance of breast cancer |
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| المؤلفون: | Liu‐Jing Wen, Yue‐Sheng Wang, Jie Zhang |
| المصدر: | IET Nanobiotechnology. 17:49-60 |
| بيانات النشر: | Institution of Engineering and Technology (IET), 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Electrical and Electronic Engineering, Biotechnology, Electronic, Optical and Magnetic Materials |
| الوصف: | The aim of this study was to provide a new effective carrier for rescuing the sensitivity of drug-resistant in breast cancer cells. Nano-gold micelles loaded with Dox and Elacridar (FP-ssD@A-E) were chemically synthesised. With the increase in the amount of Dox and Elacridar, the encapsulation rate of FP-ssD@A-E gradually increased, and the drug loading rate gradually decreased. FP-ss@A-E had a sustained-release effect. Dox, Elacridar, FP-ss@AuNPs, and FP-ssD@A-E significantly improved cell apoptosis, in which, FP-ssD@A-E was the most significant. FP-ssD@A-E significantly decreased the cell viability and improved the Dox uptake. The levels of VEGFR-1, P-gp, IL-6, and i-NOS were significantly decreased after Dox, Dox + Elacridar, FP-ss@AuNPs, and FP-ssD@A-E treatment. It was worth noting that FP-ssD@A-E had the most significant effects. The prepared FP-ssD@A-E micelles, which were spherical in shape, uniform in particle size distribution, and had good drug loading performance and encapsulation efficiency. |
| تدمد: | 1751-875X 1751-8741 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::531c0d5bc2a50627779c92b1d6ebf1e6Test https://doi.org/10.1049/nbt2.12102Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....531c0d5bc2a50627779c92b1d6ebf1e6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1751875X 17518741 |
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