Olfactory Bulbectomy Induced Oxidative and Cell Damage in Rat: Protective Effect of Melatonin
| العنوان: | Olfactory Bulbectomy Induced Oxidative and Cell Damage in Rat: Protective Effect of Melatonin |
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| المؤلفون: | Concepción Ruiz, Francisco J. Medina, Pedro Montilla, Ignacio Jimena, Isaac Túnez, Inmaculada Tasset, Montserrat Feijóo, M. del Carmen muñoz, Manuel Salcedo, J. Peña |
| المصدر: | Scopus-Elsevier |
| بيانات النشر: | Institute of Physiology of the Czech Academy of Sciences, 2010. |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Antioxidant, Physiology, medicine.medical_treatment, Apoptosis, Motor Activity, medicine.disease_cause, Antioxidants, Open field, Lipid peroxidation, Melatonin, chemistry.chemical_compound, Internal medicine, medicine, Animals, Rats, Wistar, Cell damage, Swimming, Glutathione Peroxidase, Behavior, Animal, L-Lactate Dehydrogenase, Caspase 3, Superoxide Dismutase, Brain, General Medicine, Glutathione, medicine.disease, Olfactory Bulb, Antidepressive Agents, Rats, Oxidative Stress, Endocrinology, chemistry, Lipid Peroxidation, Injections, Intraperitoneal, Oxidative stress, Behavioural despair test, medicine.drug |
| الوصف: | In this study we analyzed the effects of melatonin (Mel, 1 mg/kg ip) on behavioral changes as well as cell and oxidative damage prompted by bilaterally olfactory bulbectomy. Olfactory bulbectomy caused an increase in lipid peroxidation products and caspase-3, whereas it prompted a decrease of reduced glutathione (GSH) content and antioxidative enzymes activities. Additionally, olfactory bulbectomy induced behavioral changes characterized by the enhancement of immobility time in the forced swim test and hyperactivity in the open field test. All these changes were normalized by treatment of Mel (14 days). Our data show that Mel has a beneficial neuropsychiatric action against oxidative stress, cell damage and behavior alterations. |
| تدمد: | 1802-9973 0862-8408 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34880b6c36b003803742a43ffbf9f7e3Test https://doi.org/10.33549/physiolres.931684Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....34880b6c36b003803742a43ffbf9f7e3 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18029973 08628408 |
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