دورية أكاديمية
Reproducibility of dynamic cerebral autoregulation parameters: A multi-centre, multi-method study
| العنوان: | Reproducibility of dynamic cerebral autoregulation parameters: A multi-centre, multi-method study |
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| المؤلفون: | Sanders M.L., Claassen J.A.H.R., Aries M., Bor-Seng-Shu E., Caicedo A., Chacon M., Gommer E.D., Van Huffel S., Jara J.L., Kostoglou K., Mahdi A., Marmarelis V.Z., Mitsis G.D., Müller M., Nikolic D., Nogueira R.C., Payne S.J., Puppo C., Shin D.C., Simpson D.M., Tarumi T., Yelicich B., Zhang R., Panerai R.B., Elting J.W.J. |
| المصدر: | instname:Universidad del Rosario |
| بيانات النشر: | Institute of Physics Publishing |
| سنة النشر: | 2018 |
| المجموعة: | Universidad del Rosario, Bogotá: E-docUR |
| مصطلحات موضوعية: | Aged, Blood pressure measurement, Brain circulation, Clinical trial, Female, Homeostasis, Human, Male, Multicenter study, Reproducibility, Blood pressure determination, Cerebrovascular circulation, Humans, Reproducibility of results, Cerebral autoregulation, Method comparison, Surrogate data |
| الوصف: | Objective: Different methods to calculate dynamic cerebral autoregulation (dCA) parameters are available. However, most of these methods demonstrate poor reproducibility that limit their reliability for clinical use. Inter-centre differences in study protocols, modelling approaches and default parameter settings have all led to a lack of standardisation and comparability between studies. We evaluated reproducibility of dCA parameters by assessing systematic errors in surrogate data resulting from different modelling techniques. Approach: Fourteen centres analysed 22 datasets consisting of two repeated physiological blood pressure measurements with surrogate cerebral blood flow velocity signals, generated using Tiecks curves (autoregulation index, ARI 0-9) and added noise. For reproducibility, dCA methods were grouped in three broad categories: 1. Transfer function analysis (TFA)-like output; 2. ARI-like output; 3. Correlation coefficient-like output. For all methods, reproducibility was determined by one-way intraclass correlation coefficient analysis (ICC). Main results: For TFA-like methods the mean (SD; [range]) ICC gain was 0.71 (0.10; [0.49-0.86]) and 0.80 (0.17; [0.36-0.94]) for VLF and LF (p = 0.003) respectively. For phase, ICC values were 0.53 (0.21; [0.09-0.80]) for VLF, and 0.92 (0.13; [0.44-1.00]) for LF (p less than 0.001). Finally, ICC for ARI-like methods was equal to 0.84 (0.19; [0.41-0.94]), and for correlation-like methods, ICC was 0.21 (0.21; [0.056-0.35]). Significance: When applied to realistic surrogate data, free from the additional exogenous influences of physiological variability on cerebral blood flow, most methods of dCA modelling showed ICC values considerably higher than what has been reported for physiological data. This finding suggests that the poor reproducibility reported by previous studies may be mainly due to the inherent physiological variability of cerebral blood flow regulatory mechanisms rather than related to (stationary) random noise and the signal analysis methods. © ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | 9673334; https://repository.urosario.edu.co/handle/10336/22810Test; https://doi.org/10.1088/1361-6579/aae9fdTest |
| DOI: | 10.1088/1361-6579/aae9fd |
| الإتاحة: | https://doi.org/10.1088/1361-6579/aae9fdTest https://repository.urosario.edu.co/handle/10336/22810Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.8418D79B |
| قاعدة البيانات: | BASE |
| DOI: | 10.1088/1361-6579/aae9fd |
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