Influence of Daily Set-up Errors on Dose Distribution during Pelvis Radiotherapy
| العنوان: | Influence of Daily Set-up Errors on Dose Distribution during Pelvis Radiotherapy |
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| المؤلفون: | Vedran Rajevac, Slaven Jurković, Mladen Kasabašić, Dario Faj, Ana Ivković, Hrvoje Šobat |
| المصدر: | Arhiv za higijenu rada i toksikologiju Volume 62 Issue 3 |
| بيانات النشر: | Institute for Medical Research and Occupational Health, 2011. |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | business.industry, Set up error, Radiotherapy Planning, Computer-Assisted, Public Health, Environmental and Occupational Health, Radiotherapy Dosage, conformity index, delivered dose, external beam radiotherapy, homogeneity index, planned dose, quality assurance, Dose distribution, Radiotherapy Setup Errors, Toxicology, Patient Positioning, Pelvis, Conformity index, Radiotherapy, High-Energy, CTV, kontrola kvalitete, linearni akcelerator, planiranje radioterapije, PTV radioterapija, Medicine, Humans, Particle Accelerators, Radiotherapy, Conformal, business, Nuclear medicine, Homogeneity index, Pelvic Neoplasms |
| الوصف: | Radioterapija megavoltnim snopovima fotona linearnog akceleratora oblik je lokalnog onkološkog liječenja. Njezin je cilj predati propisanu apsorbiranu dozu ciljnom volumenu, uz što nižu dozu okolnomu zdravom tkivu. Proces se sastoji od niza koraka u kojima sudjeluje tim stručnjaka iz različitih područja. Veliki broj postupaka i ljudi uključenih u radioterapijski proces, nepouzdanosti uređaja te pomaci bolesnika i unutrašnjih organa tijekom terapije mogu uzrokovati odstupanja između planirane i stvarne raspodjele doze. U ovom radu procijenili smo utjecaj pogreške položaja bolesnika tijekom terapije na raspodjelu doze, te na veličine koje služe za procjenu kvalitete plana. Pogreške u položaju bolesnika ispitane su u skupini od 35 bolesnika. Te smo pogreške simulirali na pet bolesnika, koristeći se 3D programom za planiranje XiO (CMS Inc., St. Louis, MO, Elekta). Ispitali smo razlike u raspodjeli doze između planiranog i stvarnog položaja. Dodatno, utjecaj pogrešaka na odabir plana zračenja provjerili smo analizirajući promjene u dozno-volumnom histogramu (DVH), pokrivenost planiranog volumena (engl. PTV conformity index, CIPTV) i jednoličnost raspodjele doze u ciljnom volumenu (engl. homogeneity index, HI). Simulacije pokazuju da promjene u položaju bolesnika mogu uzrokovati značajne razlike između planirane i stvarne raspodjele doze. Kod nekih bolesnika ako se ne korigiraju pogreške, CIPTV postaje manji od 97 % što znači da plan više nije prihvatljiv za zračenje. Iznenađuje da HI nije ovisan o pomacima bolesnika kao CIPTV. Rezultati pokazuju potrebu za smanjenjem pogrešaka, što se može postići provođenjem kontrole kvalitete u radioterapiji. An external beam radiotherapy (EBRT) using megavoltage beam of linear accelerator is usually the treatment of choice in cancer patients. The goal of EBRT is to deliver the prescribed dose to the target volume, with as low as possible dose to the surrounding healthy tissue. A large number of procedures and different professions involved in radiotherapy, uncertainty of equipment and daily patient set-up errors can cause a difference between the planned and delivered dose. We investigated a part of this difference caused by measuring daily patient set-up errors for 35 patients. These set-up errors were simulated on five patients, using 3D treatment planning software XiO. The simulation investigated differences in dose distributions between the planned and shifted geometry. Additionally, we investigated the influence of the error on treatment plan selection by analysing changes in dose volume histograms, planning target volume conformity index (CIPTV), and homogeneity index (HI). Simulations showed that patient daily set-up errors can cause significant differences between the planned and actual dose distributions. Moreover, for some patients, those errors could affect the choice of treatment plan since CIPTV fell under 97 %. Surprisingly, HI was not as sensitive to set-up errors as CIPTV. Our results have confirmed the need to minimise daily set-up errors through quality assurance programmes. |
| وصف الملف: | application/pdf |
| اللغة: | Croatian |
| تدمد: | 1848-6312 0004-1254 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f89afd82937133a44e863fc655489a0Test https://hrcak.srce.hr/71779Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....7f89afd82937133a44e863fc655489a0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18486312 00041254 |
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