دورية أكاديمية
Classical Hodgkin Lymphoma in pathological anatomy department at Edgardo Rebagliati Martins National Hospital during 2015 to 2019
| العنوان: | Classical Hodgkin Lymphoma in pathological anatomy department at Edgardo Rebagliati Martins National Hospital during 2015 to 2019 |
|---|---|
| المؤلفون: | Quiñones Ávila, María del Pilar, Palomino Portilla, Eugenio Américo, Yábar Berrocal, Herbert Alejandro |
| المصدر: | Revista de la Facultad de Medicina Humana |
| بيانات النشر: | INICIB-URP |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Classical Hodgkin Lymphoma, Nodular Sclerosing, Mixed Cellularity, Lymphocyte-Rich, Lymphocyte-Depleted, Epstein Barr virus, immunohistochemistry, Health Information Technology, Medicine and Health Sciences, Public Health |
| الوصف: | Introduction: Hodgkin lymphomas are B-cell lymphoid neoplasms histologically characterized by a mixed inflammatory cellular component and few Hodgkin/Reed-Sternberg neoplastic cells. Classical Hodgkin Lymphoma (CHL) represents 10% of all lymphoma cases and 85% of all Hodgkin Lymphomas. According to the current World Health Organization classification, CHL is divided into 4 types: Nodular Sclerosing (NS), Mixed Cellularity (MC), Lymphocyte-Rich (LR), and Lymphocyte-Depleted (LD). Objetive: We reviewed all cases of Classical Hodgkin Lymphoma in the Pathological Anatomy Department at Edgardo Rebagliati Martins National Hospital during 2015 to 2019, in order to determine the most frequent type, the incidence according to age and gender, phenotypical characteristics and relation to Epstein Barr Virus (EBV). Materials and Methods: We performed a retrospective descriptive case study of Classical Hodgkin Lymphoma and its 4 clinical-pathological types in the Pathological Anatomy Department at Edgardo Rebagliati Martins National Hospital during 2015 to 2019. 72 patients were identified with Classical Hodgkin Lymphoma diagnosis, of which only 64 were selected for the study. The exclusion criteria were the absence of confirmatory immunohistochemical tests and relapse cases. Results: The most frequent type observed was Nodular Sclerosing with 34 cases (53.12%) and the least frequent type was Lymphocyte-Rich with 2 cases (3.12%). Likewise, a predominance in the male gender was observed, with 42 cases, 20 of which were Nodular Sclerosing and 14 not classified, as the most frequent types, and a greater incidence among those 41 to 50 years of age, without detection of the bimodal peak referenced in international literature. The most frequent immunohistochemical profile of Hodgkin/ Reed- Sternberg was CD15 and CD30 positive, with CD45 negative. EBV was present in 36% of cases and is more frequent in the Mixed Cellularity and Lymphocyte-Depleted types. Conclusions: Classical Hodgkin Lymphoma is a group of lymphoid neoplasms with ... |
| نوع الوثيقة: | text |
| وصف الملف: | application/pdf |
| اللغة: | unknown |
| العلاقة: | https://inicib.urp.edu.pe/rfmh/vol21/iss3/6Test; https://inicib.urp.edu.pe/cgi/viewcontent.cgi?article=1344&context=rfmhTest |
| الإتاحة: | https://inicib.urp.edu.pe/rfmh/vol21/iss3/6Test https://inicib.urp.edu.pe/cgi/viewcontent.cgi?article=1344&context=rfmhTest |
| رقم الانضمام: | edsbas.24C19E02 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |