Circulating inflammatory markers, cell-free mitochondrial DNA, cortisol, endocannabinoids, and N-acylethanolamines in female depressed outpatients
| العنوان: | Circulating inflammatory markers, cell-free mitochondrial DNA, cortisol, endocannabinoids, and N-acylethanolamines in female depressed outpatients |
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| المؤلفون: | Alexander Behnke, Anja Maria Gumpp, Roberto Rojas, Timo Sänger, Sabine Lutz-Bonengel, Dirk Moser, Gustav Schelling, Aniko Krumbholz, Iris-Tatjana Kolassa |
| المصدر: | The World Journal of Biological Psychiatry. 24:58-69 |
| بيانات النشر: | Informa UK Limited, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Psychiatry and Mental health, mental disorders, Biological Psychiatry |
| الوصف: | Major depressive disorder (MDD) involves peripheral low-grade pro-inflammatory activity. This multi-biomarker case-control study characterises the proinflammatory status in MDD beyond C-reactive protein (CRP) and Interleukin (IL)-6 levels through investigating concomitant alterations of immunoregulatory biomolecules. In 20 female MDD patients and 24 non-depressed women, circulating levels of CRP, IL-6, cortisol, selected endocannabinoids (ECs; anandamide [AEA], 2-arachidonylglycerol [2-AG]), and N-acylethanolamines (NAEs), as well as circulating cell-free mitochondrial DNA (ccf-mtDNA) were measured. We found higher serum CRP and plasma AEA levels in MDD and a positive association of CRP and AEA levels with current depressive symptoms. Blood levels of cortisol, ccf-mtDNA, 2-AG, and NAEs did depend on MDD diagnosis nor correlated with the severity of current depressive symptoms. CRP correlated positively with AEA, and AEA showed positive associations with 2-AG and NAE levels. In this study, female MDD outpatients with mild to moderate disorder severity did not substantially differ from non-depressed controls in the resting levels of multiple immunoregulatory markers in peripheral blood. Instead of investigating resting levels, future research on the role of inflammatory activity in MDD should focus on investigating the reactivity of pathways modulating the immune system upon exposure to physical and psychosocial stressors. |
| تدمد: | 1814-1412 1562-2975 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f52c2e81752dbec6b84af25e8b406e95Test https://doi.org/10.1080/15622975.2022.2070666Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....f52c2e81752dbec6b84af25e8b406e95 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18141412 15622975 |
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